Protective effects of sodium selenite on lead nitrate-induced hepatotoxicity in diabetic and non-diabetic rats

Highlights • Lead nitrate and diabetes mellitus caused hepatotoxicity. • LN caused more harmfull effects in diabetic groups compared with non-diabetic groups. • Sodium selenite protected against the hepatotoxicity induced by lead nitrate. • Protective effective of sodium selenite was not important a...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2015-09, Vol.40 (2), p.568-574
Main Authors: Kalender, Suna, Apaydin, Fatma Gökçe, Baş, Hatice, Kalender, Yusuf
Format: Article
Language:English
Subjects:
Animals
Antioxidants - administration & dosage
Antioxidants - pharmacology
Biochemical alterations
Diabetes mellitus
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - pathology
Diabetes Mellitus, Experimental - physiopathology
Emergency
Histopathology
Lead - toxicity
Lipid Peroxidation - drug effects
Liver - drug effects
Liver - metabolism
Liver - physiopathology
Liver Function Tests
Nitrates - toxicity
Oxidative stress
Oxidative Stress - drug effects
Rats
Rats, Wistar
Sodium selenite
Sodium Selenite - administration & dosage
Sodium Selenite - pharmacology
Streptozocin
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Summary:Highlights • Lead nitrate and diabetes mellitus caused hepatotoxicity. • LN caused more harmfull effects in diabetic groups compared with non-diabetic groups. • Sodium selenite protected against the hepatotoxicity induced by lead nitrate. • Protective effective of sodium selenite was not important against diabetes mellitus induced hepatotoxicity.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.08.011