Investigation of CTLA-4-318C/T gene polymorphism in cases with type 1 diabetes of Azerbaijan, Northwest Iran

Highlights • There was not any association of CTLA-4 -318C/T polymorphism with susceptibility to T1D. • CT genotype was associated with a younger age of onset. • CT genotype was associated with poor control of HbA1c level. • CT genotype was associated with positive anti-GAD or IA-2 serum autoantibod...

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Bibliographic Details
Published in:Immunology letters 2015-08, Vol.166 (2), p.134-139
Main Authors: Almasi, Shohreh, Aliparasti, Mohammad Reza, Aliasgarzadeh, Akbar, Abd-Nikfarjam, Bahareh, Hyöty, Heikki, Knip, Mikael, Feizi, Hadi, Sioofy-Khojine, Amirbabak, Rahnama, Badrossadat
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Alleles
Allergy and Immunology
Autoantibodies - immunology
Azerbaijan - epidemiology
Case-Control Studies
Child
CTLA-4
CTLA-4 Antigen - genetics
Diabetes Mellitus, Type 1 - diagnosis
Diabetes Mellitus, Type 1 - epidemiology
Diabetes Mellitus, Type 1 - genetics
Diabetes Mellitus, Type 1 - immunology
Female
GADA
Gene Frequency
Gene polymorphism
Genetic Predisposition to Disease
Genotype
Humans
IA-2A
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Type 1 diabetes
Young Adult
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Summary:Highlights • There was not any association of CTLA-4 -318C/T polymorphism with susceptibility to T1D. • CT genotype was associated with a younger age of onset. • CT genotype was associated with poor control of HbA1c level. • CT genotype was associated with positive anti-GAD or IA-2 serum autoantibodies.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2015.05.021