Chemical and microbial components of urban air PM cause seasonal variation of toxicological activity

Highlights • Inflammatory and cytotoxic effects of size segregated PM display seasonal variation. • Biological composition of PM is important factor in PM induced inflammation. • Gram negative bacteria cause higher effects than gram positive bacteria. • Varyi chemical component emerge as causative i...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2015-09, Vol.40 (2), p.375-387
Main Authors: Jalava, Pasi I, Happo, Mikko S, Huttunen, Kati, Sillanpää, Markus, Hillamo, Risto, Salonen, Raimo O, Hirvonen, Maija-Riitta
Format: Article
Language:English
Subjects:
Air Pollutants - chemistry
Air Pollutants - toxicity
Animals
Cell Line
Cell Survival - drug effects
Dose-Response Relationship, Drug
Emergency
Emission sources
Endotoxin
Endotoxins - toxicity
Finland
Humans
In Vitro Techniques
Inflammation
Interleukin-6 - metabolism
Macrophages - drug effects
Macrophages - immunology
Mice
Particle Size
Particulate matter
Particulate Matter - chemistry
Particulate Matter - toxicity
Polymyxin B - pharmacology
Road dust
Seasonal variation
Seasons
Tumor Necrosis Factor-alpha - metabolism
Urban Health
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Summary:Highlights • Inflammatory and cytotoxic effects of size segregated PM display seasonal variation. • Biological composition of PM is important factor in PM induced inflammation. • Gram negative bacteria cause higher effects than gram positive bacteria. • Varyi chemical component emerge as causative in different PM sizes.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.06.023