Cognitive enhancement in aged rats after chronic administration of Equisetum arvense L. with demonstrated antioxidant properties in vitro

The aim of this work was to verify if chronic administration of the hydroalcoholic extract of stems from Equisetum arvense (HAE) reverses the cognitive impairment in aged rats, as well as, evaluates it in vitro antioxidant properties. Chronic administration of HAE at dose of 50 mg/kg, i.p., improved...

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Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2005-07, Vol.81 (3), p.593-600
Main Authors: Guilherme dos Santos Junior, Jair, Hoffmann Martins do Monte, Fabrício, Marcela Blanco, Miriam, Maria do Nascimento Bispo Lanziotti, Vanusa, Damasseno Maia, Flávio, Kalyne de Almeida Leal, Luzia
Format: Article
Language:English
Subjects:
Age Factors
Aging
Animals
Antioxidants - pharmacology
Avoidance Learning - drug effects
Behavior, Animal - drug effects
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Catalase - metabolism
Cognition - drug effects
Dose-Response Relationship, Drug
Equisetum
Equisetum arvense
Learning
Male
Maze Learning - drug effects
Medical sciences
Memory
Memory - drug effects
Nitrites - metabolism
Oxidative stress
Plant Extracts - pharmacology
Rats
Rats, Wistar
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:The aim of this work was to verify if chronic administration of the hydroalcoholic extract of stems from Equisetum arvense (HAE) reverses the cognitive impairment in aged rats, as well as, evaluates it in vitro antioxidant properties. Chronic administration of HAE at dose of 50 mg/kg, i.p., improved both short- and long-term retention of inhibitory avoidance task and ameliorated the cognitive performance in reference and working memory version of the Morris Water Maze. No differences were found between all three groups of young controls, aged controls and EHA-treated animals with regard to the open field and elevated plus maze tests. Indeed, no toxicity manifestations were observed during treatment. In vitro assays revealed that HAE diminished the thiobarbituric acid reactive substances as well as nitrite formation, but did not alter catalase activity. Thus, the cognitive enhancement effects of the HAE may be attributed, at least in part, to it antioxidant action.
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2005.04.012