Caffeine and modafinil given during 48h sleep deprivation modulate object recognition memory and synaptic proteins in the hippocampus of the rat

•Sleep deprivation (SD) reduces novel object/location recognition memory scores.•SD also decreases the expression of synaptophysin, synapsin I and PSD-95 protein.•Caffeine and modafinil improve novel object recognition memory during SD.•Caffeine/modafinil ameliorate the reduced synaptic protein expr...

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Bibliographic Details
Published in:Behavioural brain research 2015-11, Vol.294, p.95-101
Main Authors: Wadhwa, M., Sahu, S., Kumari, P., Kauser, H., Ray, K., Panjwani, U.
Format: Article
Language:English
Subjects:
Caffeine
Modafinil
Novel object recognition memory
Sleep deprivation
Synaptic protein
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Summary:•Sleep deprivation (SD) reduces novel object/location recognition memory scores.•SD also decreases the expression of synaptophysin, synapsin I and PSD-95 protein.•Caffeine and modafinil improve novel object recognition memory during SD.•Caffeine/modafinil ameliorate the reduced synaptic protein expression during SD. We aimed to evaluate the effect of caffeine/modafinil on sleep deprivation (SD) induced alterations in recognition memory and synaptic proteins. The data revealed a beneficial effect of caffeine/modafinil against deficit in the familiar object retrieval performance and object exploration ratio after 48h SD. Caffeine treatment prevented the SD induced down-regulation of synaptophysin and synapsin I proteins with no change in PSD-95 protein in hippocampus. However, modafinil administration improved the down-regulation of synaptophysin, synapsin I and PSD-95 proteins in hippocampus. Hence, caffeine/modafinil can serve as counter measures in amelioration of SD induced consequences at behavioural and protein levels.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2015.08.002