Validation of the neutrophil-to-lymphocyte ratio as a prognostic factor in a cohort of European prostate cancer patients

Purpose Recent studies have expanded the concept that the systemic inflammatory response has an important role in the progression of several solid tumors. The neutrophil-to-lymphocyte ratio (NLR), an easily determinable marker of systemic inflammation, has been associated with clinical outcome in va...

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Bibliographic Details
Published in:World journal of urology 2015-11, Vol.33 (11), p.1661-1667
Main Authors: Langsenlehner, Tanja, Thurner, Eva-Maria, Krenn-Pilko, Sabine, Langsenlehner, Uwe, Stojakovic, Tatjana, Gerger, Armin, Pichler, Martin
Format: Article
Language:English
Subjects:
Aged
Austria - epidemiology
Disease Progression
Disease-Free Survival
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Leukocyte Count
Lymphocytes - pathology
Male
Medicine
Medicine & Public Health
Nephrology
Neutrophils - pathology
Oncology
Original Article
Prognosis
Proportional Hazards Models
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - epidemiology
Retrospective Studies
Survival Rate - trends
Urology
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Summary:Purpose Recent studies have expanded the concept that the systemic inflammatory response has an important role in the progression of several solid tumors. The neutrophil-to-lymphocyte ratio (NLR), an easily determinable marker of systemic inflammation, has been associated with clinical outcome in various cancer entities. In the present study, we validated the prognostic relevance of an elevated NLR in a cohort of European prostate cancer patients. Methods Data from 415 consecutive prostate cancer patients treated with 3D conformal radiotherapy at a single tertiary academic center from 1999 to 2007 were included in this retrospective study. Clinical progression-free survival (PFS), distant metastases-free survival (DMFS), and overall survival (OS) were assessed using the Kaplan–Meier method. To evaluate the prognostic relevance, univariate and multivariate Cox regression models were performed for each end point. Results Based on previously published studies, an NLR ≥ 5 was selected as cutoff value for external validation. Multivariate analysis identified an increased NLR as an independent prognostic factor for clinical PFS [hazard ratio (HR) 3.09, 95 % CI 1.64–5.82, p  
ISSN:0724-4983
1433-8726
DOI:10.1007/s00345-015-1494-7