Environmentally Realistic Doses of Cadmium as a Possible Etiologic Agent for Idiopathic Pathologies

• Published in: Biological trace element research 2015-11, Vol.168 (1), p.133-140
• Main Authors: Leite, Rodrigo, Peloso, Eduardo F., Gadelha, Fernanda R., Dolder, Mary A. D.
• Format: Article
• Language: English
• Subjects: Animals; Antioxidants - metabolism; Biochemistry; Biomedical and Life Sciences; Biotechnology; Cadmium; Cadmium - analysis; Cadmium Poisoning - complications; Cadmium Poisoning - epidemiology; Cadmium Poisoning - pathology; Endothelium, Vascular - drug effects; Environmental Exposure - adverse effects; Environmental perception; Fertilizers - analysis; Glutathione - metabolism; Heavy metals; Leydig Cells - pathology; Life Sciences; Lipid Peroxidation - drug effects; Male; Nutrition; Oncology; Oxidative stress; Pathology; Peroxidation; Rats; Rats, Wistar; Reactive Oxygen Species - metabolism; Testis - metabolism; Testis - pathology; Trace elements; Weight Gain - drug effects
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-015-0322-7

Cadmium is a heavy metal of increasing environmental concern that has long been associated to several human pathological processes. Recent population surveys have correlated cadmium non-occupational exposure to widespread idiopathic pathologies. Food and tobacco are reported to be the main exposure sources of cadmium to the general population, as phosphate fertilizers are rich in such a metal, thus contaminating the crops. Although its mechanisms of toxicity are not a consensus in the literature, it is well established that reactive oxygen species play a key role in this process, leading to the oxidation of several biological molecules. We have therefore assessed whether three environmentally realistic doses of cadmium alter the oxidative status of Wistar rat testis and eventually result in histological damages. Our results show that even the lowest environmental dose of cadmium was able to disturb the endogenous antioxidant system in Wistar testis, although an increase in lipid peroxidation was observed only within the group exposed to the highest environmental dose. Despite that no remarkable morphological changes were observed in any group, significant alterations in blood vessel lumen were reported for some cadmium-exposed animals, suggesting that endothelium is one of the primary targets involved in cadmium toxicity.