Immune status of health care workers to measles virus: evaluation of protective titers in four measles IgG EIAs

Highlights • Delayed measles diagnosis in a hospital poses a threat for patients and personnel. • Nowadays more health care personnel have vaccine acquired measles immunity. • We re-evaluated different immunoassays for assessing measles immunity. • Commercial EIAs fail to detect measles IgG antibodi...

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Bibliographic Details
Published in:Journal of clinical virology 2015-08, Vol.69, p.214-218
Main Authors: Dorigo-Zetsma, J.Wendelien, Leverstein-van Hall, Maurine A, Vreeswijk, Joyce, de Vries, Jutte J.C, Vossen, Ann C.T.M, ten Hulscher, Hinke I, Kerkhof, Jeroen, Smits, Gaby P, Ruijs, Wilhelmina L.M, Koopmans, Marion P.G, Binnendijk, Robert S.van
Format: Article
Language:English
Subjects:
Adult
Age Factors
Allergy and Immunology
Antibodies, Viral - blood
Antibody
Female
Health care worker
Health Personnel - statistics & numerical data
Humans
Immunoenzyme Techniques - methods
Immunoglobulin G - blood
Infant
Infectious Disease
Male
Measles
Measles - blood
Measles - immunology
Measles - prevention & control
Measles Vaccine - therapeutic use
Measles virus
Measles virus - immunology
Measles virus - isolation & purification
Middle Aged
Netherlands
Neutralization
Neutralization Tests
Protection
Vaccination
Young Adult
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Summary:Highlights • Delayed measles diagnosis in a hospital poses a threat for patients and personnel. • Nowadays more health care personnel have vaccine acquired measles immunity. • We re-evaluated different immunoassays for assessing measles immunity. • Commercial EIAs fail to detect measles IgG antibodies in at least 10% of vaccinees. • Measles immune status of health care workers should be retrievable.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2015.06.095