The modulatory effect of CA1 GABAb receptors on ketamine-induced spatial and non-spatial novelty detection deficits with respect to Ca2

Highlights • Ketamine and phaclofen impaired both spatial and non-spatial novelty detection. • Baclofen impairs spatial but not non-spatial novelty detection. • Baclofen restored spatial and modulating effect on non-spatial ketamine responses. • Phaclofen restored non-spatial and modulating effect o...

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Bibliographic Details
Published in:Neuroscience 2015-10, Vol.305, p.157-168
Main Authors: Khanegheini, A, Nasehi, M, Zarrindast, M.-R
Format: Article
Language:English
Subjects:
CA1
GABAb
ketamine
Neurology
spatial memory
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Summary:Highlights • Ketamine and phaclofen impaired both spatial and non-spatial novelty detection. • Baclofen impairs spatial but not non-spatial novelty detection. • Baclofen restored spatial and modulating effect on non-spatial ketamine responses. • Phaclofen restored non-spatial and modulating effect on spatial ketamine responses. • SKF96365 abolished spatial restoration effect by baclofen/phaclofen with ketamine.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.07.083