Effects of environmental enrichment on behavioral deficits and alterations in hippocampal BDNF induced by prenatal exposure to morphine in juvenile rats

Highlights • Prenatal morphine induces deficits at both the behavioral and the biochemical levels. • A marked reversibility of deficits was found following environmental enrichment. • Environmental enrichment alleviates disorders produced by early insults.

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Bibliographic Details
Published in:Neuroscience 2015-10, Vol.305, p.372-383
Main Authors: Ahmadalipour, A, Sadeghzadeh, J, Vafaei, A.A, Bandegi, A.R, Mohammadkhani, R, Rashidy-Pour, A
Format: Article
Language:English
Subjects:
Age Factors
Analgesics, Opioid - toxicity
Analysis of Variance
Animals
anxiety
Avoidance Learning - drug effects
BDNF
Brain-Derived Neurotrophic Factor - metabolism
enriched environment
Environment
Female
Gene Expression Regulation, Developmental - drug effects
Hippocampus - metabolism
Male
Maze Learning
memory
Mental Disorders - metabolism
Mental Disorders - nursing
Mental Disorders - pathology
Morphine - toxicity
Neurology
Pregnancy
Prenatal Exposure Delayed Effects - physiopathology
prenatal morphine
Rats
Rats, Wistar
Swimming - psychology
Time Factors
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Description
Summary:Highlights • Prenatal morphine induces deficits at both the behavioral and the biochemical levels. • A marked reversibility of deficits was found following environmental enrichment. • Environmental enrichment alleviates disorders produced by early insults.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.08.015