Neuromodulation and metamodulation by adenosine: Impact and subtleties upon synaptic plasticity regulation

Abstract Synaptic plasticity mechanisms, i.e. the sequence of events that underlies persistent changes in synaptic strength as a consequence of transient alteration in neuronal firing, are greatly influenced by the ‘chemical atmosphere’ of the synapses, that is to say by the presence of molecules at...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 2015-09, Vol.1621, p.102-113
Main Authors: Sebastião, Ana M, Ribeiro, Joaquim A
Format: Article
Language:English
Subjects:
Adenosine - metabolism
Adenosine - physiology
Adenosine formation
Adenosine receptor
Animals
Brain-Derived Neurotrophic Factor - metabolism
Brain-Derived Neurotrophic Factor - physiology
Cholinergic Neurons - metabolism
Cholinergic Neurons - physiology
Depotentiation
Endocannabinoids - metabolism
Endocannabinoids - physiology
GABAergic Neurons - metabolism
GABAergic Neurons - physiology
Glutamic Acid - metabolism
Glutamic Acid - physiology
Hippocampus
Hippocampus - metabolism
Hippocampus - physiology
Humans
Long-term depression
Long-term potentiation
Neurology
Neuronal Plasticity
Receptors, Purinergic P1 - metabolism
Synapses - physiology
Synaptic Transmission
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Synaptic plasticity mechanisms, i.e. the sequence of events that underlies persistent changes in synaptic strength as a consequence of transient alteration in neuronal firing, are greatly influenced by the ‘chemical atmosphere’ of the synapses, that is to say by the presence of molecules at the synaptic cleft able to fine-tune the activity of other molecules more directly related to plasticity. One of those fine tuners is adenosine, known for a long time as an ubiquitous neuromodulator and metamodulator and recognized early as influencing synaptic plasticity. In this review we will refer to the mechanisms that adenosine can use to affect plasticity, emphasizing aspects of the neurobiology of adenosine relevant to its ability to control synaptic functioning. This article is part of a Special Issue entitled Brain and Memory.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2014.11.008