Alterations in CA1 pyramidal neuronal intrinsic excitability mediated by Ih channel currents in a rat model of amyloid beta pathology

Highlights • Intrafrontal cortex injection of Aβ caused deficits in passive avoidance task. • Aβ treatment decreased excitability of CA1 pyramidal cells. • Decreased neuronal excitability is due to increased HCN and TRPV1 currents. • Aβ treatment caused upregulation of the mRNA of HCN1 channel in CA...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2015-10, Vol.305, p.279-292
Main Authors: Eslamizade, M.J, Saffarzadeh, F, Mousavi, S.M.M, Meftahi, G.H, Hosseinmardi, N, Mehdizadeh, M, Janahmadi, M
Format: Article
Language:English
Subjects:
Alzheimer Disease - chemically induced
Alzheimer Disease - complications
Alzheimer Disease - pathology
Amyloid beta-Peptides - toxicity
amyloid β (Aβ)
Animals
Avoidance Learning - drug effects
Avoidance Learning - physiology
CA1 pyramidal neurons
CA1 Region, Hippocampal - pathology
Capsaicin - analogs & derivatives
Capsaicin - pharmacology
Disease Models, Animal
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - agonists
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - antagonists & inhibitors
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism
Ih channel current
In Vitro Techniques
intrinsic excitability
Male
Memory Disorders - etiology
Nerve Net - drug effects
Nerve Net - physiology
Neurology
Neurons - drug effects
Neurons - physiology
Patch-Clamp Techniques
Pyrimidines - agonists
Pyrimidines - pharmacology
Rats
Rats, Wistar
Sensory System Agents - pharmacology
TRPV Cation Channels - agonists
TRPV Cation Channels - antagonists & inhibitors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Intrafrontal cortex injection of Aβ caused deficits in passive avoidance task. • Aβ treatment decreased excitability of CA1 pyramidal cells. • Decreased neuronal excitability is due to increased HCN and TRPV1 currents. • Aβ treatment caused upregulation of the mRNA of HCN1 channel in CA1 pyramidal layer.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.07.087