Profiling the host immune response to tuberculosis vaccines

Abstract There is an urgent need for improved vaccines for protection against tuberculosis (TB) disease and an immune correlate of protection would aid in the design, development and testing of a new TB vaccine candidates. The immune response to TB is likely to be multi-factorial and transcriptional...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2015-09, Vol.33 (40), p.5313-5315
Main Author: Fletcher, Helen A
Format: Article
Language:English
Subjects:
Adaptive Immunity
Adolescent
Allergy and Immunology
Antigens
Babies
BCG
BCG Vaccine - immunology
Biomarkers
Biomarkers - analysis
Clinical trials
Cohort Studies
Consortia
Gene expression
Gene Expression Profiling
Humans
Immune response
Immunologic Memory - genetics
Mycobacterium
Mycobacterium tuberculosis - immunology
Peptides
Studies
Transcriptomics
Tuberculosis
Tuberculosis - immunology
Tuberculosis - prevention & control
Tuberculosis Vaccines - immunology
Vaccine
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract There is an urgent need for improved vaccines for protection against tuberculosis (TB) disease and an immune correlate of protection would aid in the design, development and testing of a new TB vaccine candidates. The immune response to TB is likely to be multi-factorial and transcriptional profiling is a potentially useful tool for the simultaneous measurement of multiple immune processes. Although there are 16 candidate TB vaccines in clinical development the only published transcriptomics studies are from the MVA85A trials. With the publication of transcriptional signatures from the South African adolescent cohort study and the GC6 consortium also expected in 2015 the next year could see an increase of interest in the use of transcriptomics in TB vaccine development.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.07.090