Strain and sex differences in puberty onset and the effects of THC administration on weight gain and brain volumes

Highlights • Long–Evans (LER) and Wistar (WR) rats were examined during development. • Examined the immediate effects of chronic THC exposure following puberty onset. • Puberty occurred earliest in LER females. • All THC-exposed rats decreased their weight gain through the injection period. • Sex, s...

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Bibliographic Details
Published in:Neuroscience 2015-10, Vol.305, p.328-342
Main Authors: Keeley, R.J, Trow, J, McDonald, R.J
Format: Article
Language:English
Subjects:
adolescence
Animals
Animals, Newborn
Brain - anatomy & histology
Brain - drug effects
Dronabinol - pharmacology
Estrous Cycle - drug effects
Female
hippocampus
Male
Neurology
Psychotropic Drugs - pharmacology
rat
Rats
Rats, Long-Evans
Rats, Wistar
Sex Characteristics
sex difference
Sexual Maturation - drug effects
Species Specificity
strain difference
THC
Time Factors
Vagina - cytology
Vagina - drug effects
Weight Gain - drug effects
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Summary:Highlights • Long–Evans (LER) and Wistar (WR) rats were examined during development. • Examined the immediate effects of chronic THC exposure following puberty onset. • Puberty occurred earliest in LER females. • All THC-exposed rats decreased their weight gain through the injection period. • Sex, strain and THC altered hippocampal volumes.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.07.024