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Strain and sex differences in puberty onset and the effects of THC administration on weight gain and brain volumes

Highlights • Long–Evans (LER) and Wistar (WR) rats were examined during development. • Examined the immediate effects of chronic THC exposure following puberty onset. • Puberty occurred earliest in LER females. • All THC-exposed rats decreased their weight gain through the injection period. • Sex, s...

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Published in:	Neuroscience 2015-10, Vol.305, p.328-342
Main Authors:	Keeley, R.J, Trow, J, McDonald, R.J
Format:	Article
Language:	English
Subjects:	adolescence Animals Animals, Newborn Brain - anatomy & histology Brain - drug effects Dronabinol - pharmacology Estrous Cycle - drug effects Female hippocampus Male Neurology Psychotropic Drugs - pharmacology rat Rats Rats, Long-Evans Rats, Wistar Sex Characteristics sex difference Sexual Maturation - drug effects Species Specificity strain difference THC Time Factors Vagina - cytology Vagina - drug effects Weight Gain - drug effects
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description	Highlights • Long–Evans (LER) and Wistar (WR) rats were examined during development. • Examined the immediate effects of chronic THC exposure following puberty onset. • Puberty occurred earliest in LER females. • All THC-exposed rats decreased their weight gain through the injection period. • Sex, strain and THC altered hippocampal volumes.
doi_str_mv	10.1016/j.neuroscience.2015.07.024
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subjects	adolescence Animals Animals, Newborn Brain - anatomy & histology Brain - drug effects Dronabinol - pharmacology Estrous Cycle - drug effects Female hippocampus Male Neurology Psychotropic Drugs - pharmacology rat Rats Rats, Long-Evans Rats, Wistar Sex Characteristics sex difference Sexual Maturation - drug effects Species Specificity strain difference THC Time Factors Vagina - cytology Vagina - drug effects Weight Gain - drug effects
title	Strain and sex differences in puberty onset and the effects of THC administration on weight gain and brain volumes
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