The role of nitric oxide synthase signaling pathway in the Zn-induced cellular responses in MCF-7 cells

Highlights • We examine the Zn-induced cellular responses in MCF-7 cells. • Trace amount ZnCl2 increases NO level, but it has little effect on genetic level. • Excess ZnCl2 decreases NO production with the release of Ca2+. • Excess ZnCl2 further increases NO level with the activated expression of NO...

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Published in:Environmental toxicology and pharmacology 2014-11, Vol.38 (3), p.783-791
Main Authors: Zhong, Lingying, Wang, Lumei, Xu, Lurong, Liu, Qunlu, Jiang, Linlei, Zhi, Yuee, Lu, Wei, Zhou, Pei
Format: Article
Language:English
Subjects:
Acetylcysteine - pharmacology
Apoptosis
Arginine - analogs & derivatives
Arginine - pharmacology
Calcium - metabolism
Cell Proliferation - drug effects
Chlorides - pharmacology
Emergency
Female
Heavy metal
Humans
MCF-7 Cells
Nitric Oxide - metabolism
Nitric oxide synthase (NOS)
Nitric Oxide Synthase - genetics
Nitric Oxide Synthase - metabolism
Oxidative Stress - drug effects
Phosphorylation
Reactive oxygen species (ROS)
Reactive Oxygen Species - metabolism
Signal Transduction - drug effects
The alpha subunit of eukaryotic initiation factor 2 (elF2α) phosphorylation
Transcription Factors - metabolism
Zinc (Zn)
Zinc Compounds - pharmacology
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Summary:Highlights • We examine the Zn-induced cellular responses in MCF-7 cells. • Trace amount ZnCl2 increases NO level, but it has little effect on genetic level. • Excess ZnCl2 decreases NO production with the release of Ca2+. • Excess ZnCl2 further increases NO level with the activated expression of NOSs. • Acute cytotoxicity induced by ZnCl2 is related to the NOS-mediated ROS generation.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2014.09.009