Catecholamine secretion by chemical hypoxia in guinea-pig, but not rat, adrenal medullary cells: Differences in mitochondria

Highlights • Mitochondrial inhibitors induce secretion in chromaffin cells of guinea pigs, but not rats. • Mitochondrial inhibitors induce a larger decrease in cellular ATP in chromaffin cells of guinea pigs, but not rats. • The amount of F1 F0 -ATPase inhibitor factor in guinea-pig chromaffin cells...

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Bibliographic Details
Published in:Neuroscience 2015-08, Vol.301, p.134-143
Main Authors: Harada, K, Endo, Y, Warashina, A, Inoue, M
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Adrenal Medulla - drug effects
Adrenal Medulla - physiology
Animals
Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology
Catecholamines - secretion
Cell Hypoxia
chemical hypoxia
chromaffin cell
Chromaffin Cells - drug effects
Chromaffin Cells - physiology
Guinea Pigs
mitochondria
Mitochondria - drug effects
Mitochondria - physiology
Neurology
Oxidative Phosphorylation
Oxygen Consumption - drug effects
Rats
Rats, Wistar
secretion
Species Specificity
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Summary:Highlights • Mitochondrial inhibitors induce secretion in chromaffin cells of guinea pigs, but not rats. • Mitochondrial inhibitors induce a larger decrease in cellular ATP in chromaffin cells of guinea pigs, but not rats. • The amount of F1 F0 -ATPase inhibitor factor in guinea-pig chromaffin cells is larger than in rat chromaffin cells. • A large extent of reversed operation of F1 F0 -ATPase may be responsible for the inhibitor-induced secretion.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.05.080