The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s disease

• Published in: Brain, behavior, and immunity behavior, and immunity, 2015-10, Vol.49, p.280-292
• Main Authors: Mesquita, Sandro Dá, Ferreira, Ana C, Gao, Fuying, Coppola, Giovanni, Geschwind, Daniel H, Sousa, João C, Correia-Neves, Margarida, Sousa, Nuno, Palha, Joana A, Marques, Fernanda
• Format: Article
• Language: English
• Subjects: Aging; Aging - genetics; Aging - psychology; Allergy and Immunology; Alzheimer Disease - genetics; Alzheimer Disease - psychology; Alzheimer’s disease; Amyloid beta-Peptides - metabolism; Animals; Astrocytes - metabolism; Cerebrospinal fluid; Choroid plexus; Choroid Plexus - metabolism; Disease Models, Animal; Glial cells; Hippocampus; Interferon Type I - cerebrospinal fluid; Interferon Type I - genetics; Interferon-gamma - cerebrospinal fluid; Interferon-gamma - genetics; Interferons; Male; Maze Learning - physiology; Memory; Mice; Mice, Inbred C57BL; Neuroinflammation; Neurons - metabolism; Psychiatry; Transcriptome
• ISSN: 0889-1591; 1090-2139
• DOI: 10.1016/j.bbi.2015.06.008

Highlights • The choroid plexus suffers distinct alterations in aging and in Alzheimer’s disease. • The CP transcriptome reveals an early induction of type I interferons in AD mice. • Increased type I IFN gene expression is observed in the dorsal hippocampus. • Overexpression of type I IFN genes is linked with increased glial activation. • Higher levels of IFN-α in the CSF correlate with a worst spatial reference-memory.