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The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s disease
Highlights • The choroid plexus suffers distinct alterations in aging and in Alzheimer’s disease. • The CP transcriptome reveals an early induction of type I interferons in AD mice. • Increased type I IFN gene expression is observed in the dorsal hippocampus. • Overexpression of type I IFN genes is...
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| Published in: | Brain, behavior, and immunity behavior, and immunity, 2015-10, Vol.49, p.280-292 |
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| Main Authors: | , , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c579t-c72c53b2dffb1eced8cfc7ec4de795ec9382701e14a438d6a34127224255c6fb3 |
| container_end_page | 292 |
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| container_start_page | 280 |
| container_title | Brain, behavior, and immunity |
| container_volume | 49 |
| creator | Mesquita, Sandro Dá Ferreira, Ana C Gao, Fuying Coppola, Giovanni Geschwind, Daniel H Sousa, João C Correia-Neves, Margarida Sousa, Nuno Palha, Joana A Marques, Fernanda |
| description | Highlights • The choroid plexus suffers distinct alterations in aging and in Alzheimer’s disease. • The CP transcriptome reveals an early induction of type I interferons in AD mice. • Increased type I IFN gene expression is observed in the dorsal hippocampus. • Overexpression of type I IFN genes is linked with increased glial activation. • Higher levels of IFN-α in the CSF correlate with a worst spatial reference-memory. |
| doi_str_mv | 10.1016/j.bbi.2015.06.008 |
| format | article |
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| subjects | Aging Aging - genetics Aging - psychology Allergy and Immunology Alzheimer Disease - genetics Alzheimer Disease - psychology Alzheimer’s disease Amyloid beta-Peptides - metabolism Animals Astrocytes - metabolism Cerebrospinal fluid Choroid plexus Choroid Plexus - metabolism Disease Models, Animal Glial cells Hippocampus Interferon Type I - cerebrospinal fluid Interferon Type I - genetics Interferon-gamma - cerebrospinal fluid Interferon-gamma - genetics Interferons Male Maze Learning - physiology Memory Mice Mice, Inbred C57BL Neuroinflammation Neurons - metabolism Psychiatry Transcriptome |
| title | The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s disease |
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