A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection

Highlights • Central memory T cells were activated after 1st dose of hepatitis A vaccine. • Anti-viral cytokines are increased in vaccination after HAF-203-stimulation. • Memory T cells profile was activated in anti-HAV IgG poor responders. • Ag-specific proliferation after 1st dose of HAV-vaccine i...

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Bibliographic Details
Published in:Vaccine 2015-07, Vol.33 (32), p.3813-3820
Main Authors: Melgaço, Juliana Gil, Morgado, Lucas Nóbrega, Santiago, Marta Almeida, Oliveira, Jaqueline Mendes de, Lewis-Ximenez, Lia Laura, Hasselmann, Bárbara, Cruz, Oswaldo Gonçalves, Pinto, Marcelo Alves, Vitral, Claudia Lamarca
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigens
B-Lymphocytes - immunology
Cellular response
Central memory cells
Cytokines
Developing countries
Effector memory cells
Epidemiology
Female
Flow cytometry
Health care
Hepatitis
Hepatitis A - immunology
Hepatitis A - prevention & control
Hepatitis A vaccine
Hepatitis A Vaccines - administration & dosage
Hepatitis A Vaccines - immunology
Hepatitis A virus
Humans
Immunity, Cellular
Immunization
Immunologic Memory
Immunology
Infections
LDCs
Lymphocytes
Male
Single dose
Studies
T-Lymphocyte Subsets - immunology
Vaccination - methods
Vaccines
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - immunology
Young Adult
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Summary:Highlights • Central memory T cells were activated after 1st dose of hepatitis A vaccine. • Anti-viral cytokines are increased in vaccination after HAF-203-stimulation. • Memory T cells profile was activated in anti-HAV IgG poor responders. • Ag-specific proliferation after 1st dose of HAV-vaccine is similar to HAV-infection.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.06.099