A polymorphism in CCR1 / CCR3 is associated with narcolepsy

Highlights • Narcolepsy was associated with rs3181077 located upstream of CCR1 and CCR3. • CCR1 and CCR3 mRNA levels were lower in narcolepsy patients than in healthy controls. • CCR1 expression was lower in rs3181077 risk genotype (TT) carriers than in non-risk allele carriers. • Monocytes from rs3...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2015-10, Vol.49, p.148-155
Main Authors: Toyoda, Hiromi, Miyagawa, Taku, Koike, Asako, Kanbayashi, Takashi, Imanishi, Aya, Sagawa, Yohei, Kotorii, Nozomu, Kotorii, Tatayu, Hashizume, Yuji, Ogi, Kimihiro, Hiejima, Hiroshi, Kamei, Yuichi, Hida, Akiko, Miyamoto, Masayuki, Imai, Makoto, Fujimura, Yota, Tamura, Yoshiyuki, Ikegami, Azusa, Wada, Yamato, Moriya, Shunpei, Furuya, Hirokazu, Takeuchi, Masaki, Kirino, Yohei, Meguro, Akira, Remmers, Elaine F, Kawamura, Yoshiya, Otowa, Takeshi, Miyashita, Akinori, Kashiwase, Koichi, Khor, Seik-Soon, Yamasaki, Maria, Kuwano, Ryozo, Sasaki, Tsukasa, Ishigooka, Jun, Kuroda, Kenji, Kume, Kazuhiko, Chiba, Shigeru, Yamada, Naoto, Okawa, Masako, Hirata, Koichi, Mizuki, Nobuhisa, Uchimura, Naohisa, Shimizu, Tetsuo, Inoue, Yuichi, Honda, Yutaka, Mishima, Kazuo, Honda, Makoto, Tokunaga, Katsushi
Format: Article
Language:English
Subjects:
Allergy and Immunology
Asian Continental Ancestry Group
Chemokine receptor
Complex traits
Genome-Wide Association Study
Humans
Japan
Microglia
Narcolepsy
Narcolepsy - genetics
Neuroinflammation
Polymorphism, Single Nucleotide
Psychiatry
Receptors, CCR1 - genetics
Receptors, CCR3 - genetics
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Summary:Highlights • Narcolepsy was associated with rs3181077 located upstream of CCR1 and CCR3. • CCR1 and CCR3 mRNA levels were lower in narcolepsy patients than in healthy controls. • CCR1 expression was lower in rs3181077 risk genotype (TT) carriers than in non-risk allele carriers. • Monocytes from rs3181077 TT-carriers had lower migration ability than non-risk allele carriers.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2015.05.003