Compensatory restorative processes and operant reflexes in rats after neurotoxin lesioning of the inferior olive

Studies on rats showed that complete neurotoxin lesioning of the inferior olive obviated the possibility of developing and restoring previously learned operant balance reflexes. Motor deficit and compensatory-restorative processes in rats treated with 3-acetylpyridine and high section of the dorsola...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 1999-11, Vol.29 (6), p.657-663
Main Authors: Fanardzhyan, V V, Oganesyan, E A, Melik-Musyan, A B, Papoyan, E V, Govorkyan, O V
Format: Article
Language:English
Subjects:
3-acetylpyridine
Adaptation, Psychological - physiology
Animals
Conditioning, Operant - physiology
Harmaline - toxicity
Male
Neural Pathways - cytology
Neural Pathways - physiology
Neurotoxins - toxicity
Olivary Nucleus - physiology
Pyridines - toxicity
Rats
Red Nucleus - cytology
Red Nucleus - physiology
Spinal Cord - cytology
Spinal Cord - physiology
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Summary:Studies on rats showed that complete neurotoxin lesioning of the inferior olive obviated the possibility of developing and restoring previously learned operant balance reflexes. Motor deficit and compensatory-restorative processes in rats treated with 3-acetylpyridine and high section of the dorsolateral funiculus of the spinal cord depended directly on the level of disruption of the inferior olive. Prolonged observation of rats with incomplete lesions to the inferior olive revealed improvements in the compensation of motor lesions and stabilization of operant reflexes.
ISSN:0097-0549
1573-899X
DOI:10.1007/BF02462480