Role of topology in complex functional networks of beta cells

The activity of pancreatic β cells can be described by biological networks of coupled nonlinear oscillators that, via electrochemical synchronization, release insulin in response to augmented glucose levels. In this work, we analyze the emergent behavior of regular and percolated β-cells clusters th...

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Bibliographic Details
Published in:Physical review. E, Statistical, nonlinear, and soft matter physics Statistical, nonlinear, and soft matter physics, 2015-10, Vol.92 (4), p.042702-042702, Article 042702
Main Authors: Cherubini, Christian, Filippi, Simonetta, Gizzi, Alessio, Loppini, Alessandro
Format: Article
Language:English
Subjects:
Animals
Computer Simulation
Gap Junctions - physiology
Glucose - metabolism
Humans
Insulin-Secreting Cells - physiology
Membrane Potentials - physiology
Mice
Models, Biological
Periodicity
Stochastic Processes
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Summary:The activity of pancreatic β cells can be described by biological networks of coupled nonlinear oscillators that, via electrochemical synchronization, release insulin in response to augmented glucose levels. In this work, we analyze the emergent behavior of regular and percolated β-cells clusters through a stochastic mathematical model where "functional" networks arise. We show that the emergence and robustness of the synchronized dynamics depend both on intrinsic and extrinsic parameters. In particular, cellular noise level, glucose concentration, network spatial architecture, and cell-to-cell coupling strength are the key factors for the generation of a rhythmic and robust activity. Their role in the functional network topology associated with β-cells clusters is analyzed and discussed.
ISSN:1539-3755
1550-2376
DOI:10.1103/physreve.92.042702