Controllable Drug Release System in Living Cells Triggered by Enzyme–Substrate Recognition

Vehicles can deliver the drug molecules into cells, yet immunoreaction of the commonly used capping agents and release triggers limit their biomedical use. This shortcoming might be circumvented through replacing these chemicals with certain biomolecules. Here, we show a new and facile way to encaps...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2015-12, Vol.7 (48), p.26811-26818
Main Authors: Liu, Pengchang, Wang, Xiaoliang, Hiltunen, Kalervo, Chen, Zhijun
Format: Article
Language:English
Subjects:
Delayed-Action Preparations
Drug Delivery Systems
Drug Liberation
Glutathione - metabolism
Glutathione Transferase - metabolism
Microbial Viability
Microscopy, Confocal
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Porosity
Rhodamines - chemistry
Saccharomyces cerevisiae - cytology
Silicon Dioxide - chemistry
Substrate Specificity
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Summary:Vehicles can deliver the drug molecules into cells, yet immunoreaction of the commonly used capping agents and release triggers limit their biomedical use. This shortcoming might be circumvented through replacing these chemicals with certain biomolecules. Here, we show a new and facile way to encapsulate the drug delivery vehicles and release the cargos in a highly controllable manner via modulating supramolecular interactions between enzyme, substrate, and vehicle. The cargo release from the vehicles within cells can be achieved upon substrate treatment. Yeast cells were used, allowing for a fast and cost-effective way for imaging and morphological analysis. We believe this new platform can be readily extended to various carrier systems for different purposes based on shifting the recognition pattern of enzyme–substrate pairs.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.5b08914