Assessment of Nephroprotective Potential of Histochrome during Induced Arterial Hypertension

Magnetic resonance tomography was employed to verify endothelial dysfunction of renal arteries in Wistar and OXYS rats under conditions of induced arterial hypertension. Angiography revealed changes in the size and form of renal arteries of hypertensive animals. In hypertensive rats, histochrome exe...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2015-12, Vol.160 (2), p.223-227
Main Authors: Agafonova, I. G., Bogdanovich, R. N., Kolosova, N. G.
Format: Article
Language:English
Subjects:
Animals
Anticoagulants - therapeutic use
Biomedical and Life Sciences
Biomedicine
Blood Pressure - drug effects
Cell Biology
Hypertension
Hypertension - drug therapy
Internal Medicine
Laboratory Medicine
Magnetic Resonance Imaging
Naphthoquinones - therapeutic use
Pathology
Rats
Rats, Wistar
Renal Artery - drug effects
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Summary:Magnetic resonance tomography was employed to verify endothelial dysfunction of renal arteries in Wistar and OXYS rats under conditions of induced arterial hypertension. Angiography revealed changes in the size and form of renal arteries of hypertensive animals. In hypertensive rats, histochrome exerted a benevolent therapeutic effect in renal arteries: it decreased BP, diminished thrombus formation in fi ne capillaries and arterioles, demonstrated the anticoagulant properties, partially improved endothelial dysfunction of small renal arteries, and up-regulated the glomerular filtration.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-015-3134-z