Prognostic Implications of the SUVmax of Primary Tumors and Metastatic Lymph Node Measured by 18F-FDG PET in Patients With Uterine Cervical Cancer: A Meta-analysis

PURPOSEWe conducted a meta-analysis to evaluate the prognostic value of the SUVmax measured in pretreatment primary lesions and metastatic lymph nodes (LNs) on F-FDG PET scans in patients with uterine cervical cancer. METHODSA systematic search of EMBASE and MEDLINE was performed using the keywords...

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Published in:Clinical nuclear medicine 2016-01, Vol.41 (1), p.34-40
Main Authors: Sarker, Azmal, Im, Hyung-Jun, Cheon, Gi Jeong, Chung, Hyun Hoon, Kang, Keon Wook, Chung, June-Key, Kim, E Edmund, Lee, Dong Soo
Format: Article
Language:English
Subjects:
Female
Fluorodeoxyglucose F18
Humans
Lymphatic Metastasis
Positron-Emission Tomography - methods
Prognosis
Uterine Cervical Neoplasms - diagnostic imaging
Uterine Cervical Neoplasms - pathology
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Summary:PURPOSEWe conducted a meta-analysis to evaluate the prognostic value of the SUVmax measured in pretreatment primary lesions and metastatic lymph nodes (LNs) on F-FDG PET scans in patients with uterine cervical cancer. METHODSA systematic search of EMBASE and MEDLINE was performed using the keywords “positron emission tomography (PET),” “uterine cervical cancer,” and “prognosis.” Event-free survival and overall survival were evaluated as outcomes. The impact of SUVmax on survival was measured by the effect size of the hazard ratio (HR). RESULTSFourteen eligible studies including 1150 patients were analyzed. Patients with a high primary SUVmax showed a worse prognosis, with an HR of 2.66 (95% confidence interval [CI], 1.90–3.74; P < 0.00001) for adverse events and an HR of 2.45 (95% CI, 1.74–3.45; P < 0.00001) for death. Patients with high SUVmax in metastatic pelvic LN (PLN) showed a worse prognosis, with an HR of 2.92 (95% CI, 1.94–4.39; P < 0.00001) for adverse events and an HR of 2.66 (95% CI, 1.60–4.43; P = 0.0002) for SUVmax in PLN for death. In addition, high SUVmax in metastatic para-aortic LN was associated with a worse prognosis, with an HR of 4.41 (95% CI, 2.32–8.38; P < 0.00001) for death. CONCLUSIONSPatients with uterine cervical cancer and a high SUVmax primary lesion, PLN, or para-aortic LN are at higher risk of adverse events or death.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000001049