Elevated RABEX-5 protein expression predicts poor prognosis in combined small cell lung cancer

RABEX-5 has been studied in various solid tumors, but its role in combined small cell lung cancer (C-SCLC) remains unknown. This study aimed to investigate the expression, the potential relevance to clinicopathological characters and prognostic significance of RABEX-5 in patients with C-SCLC. Fifty-...

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Bibliographic Details
Published in:Tumor biology 2015-11, Vol.36 (11), p.8287-8293
Main Authors: Zhang, Fuliang, Zhang, Meng, Hu, Guohua, Cai, Qiling, Xu, Tongbai
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - biosynthesis
Biomarkers, Tumor - genetics
Biomedical and Life Sciences
Biomedicine
Cancer Research
Disease-Free Survival
Female
Gene Expression Regulation, Neoplastic
Guanine Nucleotide Exchange Factors - biosynthesis
Guanine Nucleotide Exchange Factors - genetics
Humans
Kaplan-Meier Estimate
Lung cancer
Male
Medical prognosis
Middle Aged
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - pathology
Prognosis
Proteins
Research Article
RNA, Messenger - genetics
Small Cell Lung Carcinoma - genetics
Small Cell Lung Carcinoma - pathology
Studies
Tumors
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Summary:RABEX-5 has been studied in various solid tumors, but its role in combined small cell lung cancer (C-SCLC) remains unknown. This study aimed to investigate the expression, the potential relevance to clinicopathological characters and prognostic significance of RABEX-5 in patients with C-SCLC. Fifty-two C-SCLC patients who received radical surgery were enrolled in our study. The clinicalpathological data and survival time were reviewed. The mRNA and protein expression of RABEX-5 from the paired tumor tissues and adjacent normal tissues were determined, and its relationship with clinicalpathological variables and prognosis was analyzed. Univariate and multivariate analyses were performed to investigate the prognostic significance of RABEX-5 for C-SCLC. The mRNA and protein expression level of RABEX-5 was significantly elevated in C-SCLC tissues. The increased RABEX-5 protein expression was correlated with clinical stage ( p  = 0.011) and tumor recurrence ( p  = 0.006). The median OS and DFS was significantly shorter in the high RABEX-5 expression group compared to low RABEX-5 expression group (OS: 12.0 vs. 21.7 months, p  = 0.014; DFS: 6.7 vs. 11.8 months, p  = 0.005). Multivariate Cox analysis indicated that high RABEX-5 protein expression was an independent prognostic factor for OS and DFS ( p  
ISSN:1010-4283
1423-0380
DOI:10.1007/s13277-015-3562-4