Gut Microbiota Interacts With Brain Microstructure and Function

Context: Evidence from animals suggests that gut microbiota affects brain structure and function but evidence in humans is scarce. Objective: This study sought to evaluate potential interactions among gut microbiota composition, brain microstructure, and cognitive tests in obese and nonobese subject...

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Published in:The journal of clinical endocrinology and metabolism 2015-12, Vol.100 (12), p.4505-4513
Main Authors: Fernandez-Real, José-Manuel, Serino, Matteo, Blasco, Gerard, Puig, Josep, Daunis-i-Estadella, Josep, Ricart, Wifredo, Burcelin, Remy, Fernández-Aranda, Fernando, Portero-Otin, Manuel
Format: Article
Language:English
Subjects:
Actinobacteria
Adult
Aged
Attention - physiology
Biodiversity
Body Composition - physiology
Brain - physiology
Brain - ultrastructure
Cognition
Cross-Sectional Studies
Diffusion Tensor Imaging
Female
Humans
Male
Microbiota - physiology
Middle Aged
Neuropsychological Tests
Obesity - microbiology
Obesity - psychology
Reaction Time - physiology
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Summary:Context: Evidence from animals suggests that gut microbiota affects brain structure and function but evidence in humans is scarce. Objective: This study sought to evaluate potential interactions among gut microbiota composition, brain microstructure, and cognitive tests in obese and nonobese subjects. Design, Setting, and Participants: This was a cross-sectional study at a tertiary hospital including 20 consecutive obese and 19 nonobese subjects similar in age and sex. Main Outcome Measures: Gut microbiota (16S bacterial gene pyrosequencing), brain microstructure (diffusion tensor imaging of brain white and gray matter and R2* sequences in magnetic resonance imaging) and cognitive tests. Results: Hierarchical clustering revealed a specific gut microbiota–brain map profile for obese individuals who could be discriminated from nonobese subjects (accuracy of 0.81). Strikingly, Shannon index was linked to R2* and fractional anisotropy of the hypothalamus, caudate nucleus, and hippocampus, suggesting sparing of these brain structures with increased bacterial biodiversity. Microbiota profile also clustered with cognitive function. The relative abundance of Actinobacteria phylum was linked not only to magnetic resonance imaging diffusion tensor imaging variables in the thalamus, hypothalamus, and amygdala but also to cognitive test scores related to speed, attention, and cognitive flexibility. Conclusions: In sum, obesity status affects microbiota–brain microstructure and function crosstalk.
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2015-3076