Induction of a physiologically active brain-derived neurotrophic factor in the infant rat brain by peripheral administration of 4-methylcatechol

Effects of 4-methylcatechol (4MC), a known potent stimulator of nerve growth factor (NGF) synthesis, on expression of brain-derived neurotrophic factor (BDNF) mRNA and BDNF-like immunoreactivity (BDNF-LI) was investigated in infant rat brains. A single intraperitoneal administration of 4MC caused tr...

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Bibliographic Details
Published in:Neuroscience letters 1999-10, Vol.274 (2), p.115-118
Main Authors: FUKUMITSU, H, SOMETANI, A, OHMIYA, M, NITTA, A, NOMOTO, H, FURUKAWA, Y, FURUKAWA, S
Format: Article
Language:English
Subjects:
4-Methylcatechol
Age Factors
Animals
Animals, Newborn
Antibodies
Biological and medical sciences
Blotting, Western
Brain Chemistry - drug effects
Brain Chemistry - genetics
Brain-Derived Neurotrophic Factor - analysis
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - immunology
Calbindins
Catechols - pharmacology
Cerebral Cortex - chemistry
Development. Senescence. Regeneration. Transplantation
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental - drug effects
Hippocampus - chemistry
In Situ Hybridization
Male
Neuroprotective Agents - pharmacology
Rats
Rats, Wistar
RNA, Messenger - analysis
S100 Calcium Binding Protein G - analysis
S100 Calcium Binding Protein G - immunology
Vertebrates: nervous system and sense organs
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Summary:Effects of 4-methylcatechol (4MC), a known potent stimulator of nerve growth factor (NGF) synthesis, on expression of brain-derived neurotrophic factor (BDNF) mRNA and BDNF-like immunoreactivity (BDNF-LI) was investigated in infant rat brains. A single intraperitoneal administration of 4MC caused transient increases in the levels of BDNF mRNA and BDNF-LI in neurons of the cerebral cortex from 1 to 3 h and 3 to 12 h, respectively, after the injection. Repetitive injections of 4MC to newborn rats (12-h intervals for 10 days) caused a marked and dose-dependent elevation of the level of BDNF mRNA in the whole brain besides elevating the number of cells containing calbindin D-28 and enhancing its immunoreactive intensity in the pyriform cortex and hippocampus. These findings demonstrate that 4MC stimulates de novo synthesis of BDNF in the infant rat brain, resulting in acceleration of the developmental expression of calbindin D-28.
ISSN:0304-3940
1872-7972
DOI:10.1016/s0304-3940(99)00691-6