The potential of phage display virions expressing malignant tumor specific antigen MAGE-A1 epitope in murine model

The tumor specific antigen epitope melanoma antigen A1 161–169 (MAGE-A1 161–169) was displayed on the major protein (pVIII) of the filamentous bacteriophage ( fd). The immune responses of the phage display particles expressing MAGE-A1 161–169 in mice were studied. Using phage display particles as va...

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Bibliographic Details
Published in:Vaccine 2005-09, Vol.23 (40), p.4860-4866
Main Authors: Fang, Jinbo, Wang, Guiyun, Yang, Qiong, Song, Jinna, Wang, Ye, Wang, Li
Format: Article
Language:English
Subjects:
Animals
Anti-tumor immunity
Antigens, Neoplasm
Applied microbiology
Bacteriology
Bacteriophage display
Biological and medical sciences
Cancer Vaccines - immunology
Cell Line
Cell Line, Tumor
Cytotoxicity Tests, Immunologic
Epitopes - genetics
Epitopes - immunology
Fundamental and applied biological sciences. Psychology
Genes
Hypersensitivity, Delayed
Immune system
Immunotherapy
Killer Cells, Natural - immunology
Medical sciences
Melanoma
Melanoma-Specific Antigens
Mice
Mice, Inbred C57BL
Microbiology
Neoplasm Proteins - immunology
Neoplasm Transplantation
Peptide Library
Polyethylene glycol
Tumor specific antigen
Tumors
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Virion - immunology
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Summary:The tumor specific antigen epitope melanoma antigen A1 161–169 (MAGE-A1 161–169) was displayed on the major protein (pVIII) of the filamentous bacteriophage ( fd). The immune responses of the phage display particles expressing MAGE-A1 161–169 in mice were studied. Using phage display particles as vaccine was effective in affording protection from tumor growth, inducing growth control of established tumors and prolonging survival of tumor-bearing mice. The hybrid phage particles elicited MAGE-A1 161–169 specific CTL responses, NK activity and DTH. Our results showed that the phage display particles might be a new vaccine candidate for tumor-associated antigen epitope in cancer immunotherapy.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2005.05.024