Teratogenicity and developmental toxicity of chlorpyrifos Maternal exposure during organogenesis in mice

Chlorpyrifos, an organophosphate pesticide, was evaluated for potential teratogenicity and developmental toxicity in mice. Pregnant females were given a single intraperitoneal injection (40 or 80 mg/kg) on day 10 of gestation and fetuses were evaluated on gestation day 17. At 80 mg/kg, chlorpyrifos...

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Bibliographic Details
Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2005-07, Vol.20 (2), p.267-271
Main Authors: YING TIAN, ISHIKAWA, Hitoshi, YAMAGUCHI, Tomoko, YAMAUCHI, Toru, YOKOYAMA, Kazuhito
Format: Article
Language:English
Subjects:
Abnormalities, Drug-Induced - pathology
Abnormalities, Multiple - pathology
Animals
Biological and medical sciences
Chlorpyrifos - administration & dosage
Chlorpyrifos - toxicity
Cleft Palate - chemically induced
Dose-Response Relationship, Drug
Embryology: invertebrates and vertebrates. Teratology
Female
Fetal Resorption - chemically induced
Fundamental and applied biological sciences. Psychology
Hernia, Abdominal - chemically induced
Injections, Intraperitoneal
Insecticides - toxicity
Maternal Exposure - adverse effects
Medical sciences
Mice
Mice, Inbred ICR
Neural Tube Defects - chemically induced
Organogenesis - drug effects
Pesticides, fertilizers and other agrochemicals toxicology
Polydactyly - chemically induced
Pregnancy
Spine - abnormalities
Spine - drug effects
Teratogens
Teratology. Teratogens
Time Factors
Toxicology
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Summary:Chlorpyrifos, an organophosphate pesticide, was evaluated for potential teratogenicity and developmental toxicity in mice. Pregnant females were given a single intraperitoneal injection (40 or 80 mg/kg) on day 10 of gestation and fetuses were evaluated on gestation day 17. At 80 mg/kg, chlorpyrifos treatment resulted in a significant reduction in numbers of live fetuses, and increase in resorptions, versus control litters. There was no indication of maternal toxicity. External and skeletal malformations were observed at 80 mg/kg, but not 40 mg/kg. Rates of fetuses with cleft palate increased significantly (p
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2005.01.012