Leptolide, a New Furanocembranolide Diterpene from Leptogorgia alba

Six furanocembranolides (1-6) and one pseudopterolide (7) have been isolated from the octocorals Leptogorgia alba and Leptogorgia rigida, collected on the Pacific coast of Panama. Compound 1, named leptolide, has a new structure closely related to the neurotoxin lophotoxin (3). The X-ray structures...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-04, Vol.68 (4), p.614-616
Main Authors: GUTIéRREZ, Marcelino, CAPSON, Todd L., GUZMáN, Héctor M., GONZáLEZ, José, ORTEGA-BARRíA, Eduardo, QUIñOá, Emilio, RIGUERA, Ricardo
Format: Article
Language:English
Subjects:
Alcyonaria
Animals
Anthozoa - chemistry
Biological and medical sciences
Bridged-Ring Compounds - chemistry
Bridged-Ring Compounds - isolation & purification
Bridged-Ring Compounds - pharmacology
Crystallography, X-Ray
Diterpenes - chemistry
Diterpenes - isolation & purification
Diterpenes - pharmacology
Drug Resistance
Furans - chemistry
Furans - isolation & purification
Furans - pharmacology
General pharmacology
Gorgonacea
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Leptogorgia
Marine
Medical sciences
Molecular Conformation
Molecular Structure
Pacific Ocean
Panama
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plasmodium falciparum
Plasmodium falciparum - drug effects
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Summary:Six furanocembranolides (1-6) and one pseudopterolide (7) have been isolated from the octocorals Leptogorgia alba and Leptogorgia rigida, collected on the Pacific coast of Panama. Compound 1, named leptolide, has a new structure closely related to the neurotoxin lophotoxin (3). The X-ray structures of 1-3 were determined, and the absolute configurations of 2-7 are discussed. Compounds 1-7 were evaluated in vitro against drug-resistant Plasmodium falciparum.
ISSN:0163-3864
1520-6025
DOI:10.1021/np049745z