Talc pleurodesis improves survival of patients with malignant pleural effusions: case-control study

Summary Aim The aim of this study is to investigate whether there was a considerable difference in the survival of patients with malignant pleural effusion (MPE) depending on the pleural effusion treatment option. Methods One hundred and seven patients with proven MPE (metastatic lung and breast can...

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Bibliographic Details
Published in:Wiener Klinische Wochenschrift 2015-12, Vol.127 (23-24), p.963-969
Main Authors: Korsic, Marta, Badovinac, Sonja, Cucevic, Branka, Janevski, Zoran
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Case-Control Studies
Croatia - epidemiology
Endocrinology
Female
Gastroenterology
Humans
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Pleural Effusion, Malignant - mortality
Pleural Effusion, Malignant - therapy
Pleurodesis - methods
Pleurodesis - mortality
Pneumology/Respiratory System
Prevalence
Retrospective Studies
Risk Factors
Short Report
Survival Rate
Talc - administration & dosage
Tissue Adhesives - administration & dosage
Treatment Outcome
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Summary:Summary Aim The aim of this study is to investigate whether there was a considerable difference in the survival of patients with malignant pleural effusion (MPE) depending on the pleural effusion treatment option. Methods One hundred and seven patients with proven MPE (metastatic lung and breast cancer) were included in the retrospective study. Fifty six patients were treated with talc pleurodesis and a control group of 51 patients with similar characteristics (in age, sex and disease) were treated with serial thoracentesis. The patients of both groups underwent chemotherapy and/or radiotherapy. The overall survival and the survival in subgroups of patients with different tumour types and different performance status (PS) equal 1, 2 and 3 were compared. Results The patients who underwent talc pleurodesis had a longer average survival interval (MS) than the patients without such a treatment ( n  = 56; MS = 21,5 and n  = 51; MS = 9 weeks, respectively; p  
ISSN:0043-5325
1613-7671
DOI:10.1007/s00508-015-0716-8