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Effect of millimeter waves on cyclophosphamide induced suppression of the immune system
The effect of millimeter electromagnetic waves (MWs) on cyclophosphamide (CPA) induced toxicity to leukocytes, bone marrow cells, and T‐cell‐mediated immunity was examined. For studying the effect of MWs on CPA induced leukopenia and myelosuppression, BALB/C mice were irradiated for 3 days, 30 min e...
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| Published in: | Bioelectromagnetics 2002-12, Vol.23 (8), p.614-621 |
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| container_title | Bioelectromagnetics |
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| creator | Logani, Mahendra K. Anga, Altaf Szabo, Imre Agelan, Alexis Irizarry, Armando R. Ziskin, Marvin C. |
| description | The effect of millimeter electromagnetic waves (MWs) on cyclophosphamide (CPA) induced toxicity to leukocytes, bone marrow cells, and T‐cell‐mediated immunity was examined. For studying the effect of MWs on CPA induced leukopenia and myelosuppression, BALB/C mice were irradiated for 3 days, 30 min each day, prior to administration of CPA (200 mg/kg). MWs were produced with a Russian made YAV‐1 generator. The device produced 42.2 ± 0.2 GHz modulated wave radiation through a 10 mm × 20 mm rectangular output horn. The animals were irradiated on the nose area. Peak SAR and incident power density were measured as 622 ± 100 W/kg and 31 ± 5 mW/cm2, respectively. For studying the effect of MWs on CPA induced suppression of T‐cell mediated immunity, a delayed type hypersensitivity (DTH) assay in mouse skin was used. The DTH reaction in mouse skin was induced by topical application of dinitrochlorobenzene (DNCB) and quantified by measuring the increase in ear thickness and by histological examination. Treatment of animals with CPA significantly (P |
| doi_str_mv | 10.1002/bem.10058 |
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For studying the effect of MWs on CPA induced leukopenia and myelosuppression, BALB/C mice were irradiated for 3 days, 30 min each day, prior to administration of CPA (200 mg/kg). MWs were produced with a Russian made YAV‐1 generator. The device produced 42.2 ± 0.2 GHz modulated wave radiation through a 10 mm × 20 mm rectangular output horn. The animals were irradiated on the nose area. Peak SAR and incident power density were measured as 622 ± 100 W/kg and 31 ± 5 mW/cm2, respectively. For studying the effect of MWs on CPA induced suppression of T‐cell mediated immunity, a delayed type hypersensitivity (DTH) assay in mouse skin was used. The DTH reaction in mouse skin was induced by topical application of dinitrochlorobenzene (DNCB) and quantified by measuring the increase in ear thickness and by histological examination. Treatment of animals with CPA significantly (P < 0.05) reduced leukocyte and bone marrow cell population, but MW irradiation did not show any significant protection from the immunosuppressive effects of CPA. Furthermore, MW irradiation did not protect the animals from CPA induced suppression of T‐cell mediated immunity. Bioelectromagnetics 23:614–621, 2002. © 2002 Wiley‐Liss, Inc.</description><identifier>ISSN: 0197-8462</identifier><identifier>EISSN: 1521-186X</identifier><identifier>DOI: 10.1002/bem.10058</identifier><identifier>PMID: 12395417</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Administration, Topical ; Animals ; Body Weight - drug effects ; Body Weight - radiation effects ; Bone Marrow Cells - drug effects ; Bone Marrow Cells - radiation effects ; Cyclophosphamide - administration & dosage ; delayed type hypersensitivity ; Dinitrochlorobenzene - administration & dosage ; Dinitrochlorobenzene - pharmacology ; Drug Hypersensitivity - immunology ; Ear ; Hypersensitivity, Delayed - chemically induced ; Hypersensitivity, Delayed - immunology ; Immune Tolerance - drug effects ; Immune Tolerance - immunology ; Immune Tolerance - radiation effects ; Immunity, Cellular - drug effects ; Immunity, Cellular - radiation effects ; Immunosuppression - methods ; Injections, Intraperitoneal ; Leukocyte Count ; Leukocytes - drug effects ; Leukocytes - radiation effects ; leukopenia ; Leukopenia - chemically induced ; Male ; Mice ; Mice, Inbred BALB C ; Microwaves ; myelosuppression ; Nose - immunology ; Reference Values ; Skin - drug effects ; Skin - immunology ; Skin - radiation effects ; T-cell mediated immunity ; T-Lymphocytes, Regulatory - drug effects ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - radiation effects ; Whole-Body Irradiation</subject><ispartof>Bioelectromagnetics, 2002-12, Vol.23 (8), p.614-621</ispartof><rights>Copyright © 2002 Wiley‐Liss, Inc.</rights><rights>Copyright 2002 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3908-bf0d74ee0f8af4c8613104710258f3d6180691b91acc462706bf0099dce6b2463</citedby><cites>FETCH-LOGICAL-c3908-bf0d74ee0f8af4c8613104710258f3d6180691b91acc462706bf0099dce6b2463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12395417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Logani, Mahendra K.</creatorcontrib><creatorcontrib>Anga, Altaf</creatorcontrib><creatorcontrib>Szabo, Imre</creatorcontrib><creatorcontrib>Agelan, Alexis</creatorcontrib><creatorcontrib>Irizarry, Armando R.</creatorcontrib><creatorcontrib>Ziskin, Marvin C.</creatorcontrib><title>Effect of millimeter waves on cyclophosphamide induced suppression of the immune system</title><title>Bioelectromagnetics</title><addtitle>Bioelectromagnetics</addtitle><description>The effect of millimeter electromagnetic waves (MWs) on cyclophosphamide (CPA) induced toxicity to leukocytes, bone marrow cells, and T‐cell‐mediated immunity was examined. For studying the effect of MWs on CPA induced leukopenia and myelosuppression, BALB/C mice were irradiated for 3 days, 30 min each day, prior to administration of CPA (200 mg/kg). MWs were produced with a Russian made YAV‐1 generator. The device produced 42.2 ± 0.2 GHz modulated wave radiation through a 10 mm × 20 mm rectangular output horn. The animals were irradiated on the nose area. Peak SAR and incident power density were measured as 622 ± 100 W/kg and 31 ± 5 mW/cm2, respectively. For studying the effect of MWs on CPA induced suppression of T‐cell mediated immunity, a delayed type hypersensitivity (DTH) assay in mouse skin was used. The DTH reaction in mouse skin was induced by topical application of dinitrochlorobenzene (DNCB) and quantified by measuring the increase in ear thickness and by histological examination. Treatment of animals with CPA significantly (P < 0.05) reduced leukocyte and bone marrow cell population, but MW irradiation did not show any significant protection from the immunosuppressive effects of CPA. Furthermore, MW irradiation did not protect the animals from CPA induced suppression of T‐cell mediated immunity. Bioelectromagnetics 23:614–621, 2002. © 2002 Wiley‐Liss, Inc.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Body Weight - radiation effects</subject><subject>Bone Marrow Cells - drug effects</subject><subject>Bone Marrow Cells - radiation effects</subject><subject>Cyclophosphamide - administration & dosage</subject><subject>delayed type hypersensitivity</subject><subject>Dinitrochlorobenzene - administration & dosage</subject><subject>Dinitrochlorobenzene - pharmacology</subject><subject>Drug Hypersensitivity - immunology</subject><subject>Ear</subject><subject>Hypersensitivity, Delayed - chemically induced</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Immune Tolerance - drug effects</subject><subject>Immune Tolerance - immunology</subject><subject>Immune Tolerance - radiation effects</subject><subject>Immunity, Cellular - drug effects</subject><subject>Immunity, Cellular - radiation effects</subject><subject>Immunosuppression - methods</subject><subject>Injections, Intraperitoneal</subject><subject>Leukocyte Count</subject><subject>Leukocytes - drug effects</subject><subject>Leukocytes - radiation effects</subject><subject>leukopenia</subject><subject>Leukopenia - chemically induced</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microwaves</subject><subject>myelosuppression</subject><subject>Nose - immunology</subject><subject>Reference Values</subject><subject>Skin - drug effects</subject><subject>Skin - immunology</subject><subject>Skin - radiation effects</subject><subject>T-cell mediated immunity</subject><subject>T-Lymphocytes, Regulatory - drug effects</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - radiation effects</subject><subject>Whole-Body Irradiation</subject><issn>0197-8462</issn><issn>1521-186X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNp1kE1P20AQhldVUQkfh_4B5FOlHkxm_bEfx5aGgBRoD0CiXlb2elZZ8MbGawP592xIKKeeZqR53leah5CvFE4pQDIu0W2WXHwiI5onNKaCLT6TEVDJY5GxZJ8ceH8PAEJA-oXs0ySVeUb5iMwnxqDuo8ZEzta1ddhjFz0XT-ijZhXpta6bdtn4dlk4W2FkV9WgsYr80LYdem8DFLL9MpycG1YY-bXv0R2RPVPUHo9385Dcnk9uzi7i2e_p5dmPWaxTCSIuDVQ8QwQjCpNpwWhKIeMUklyYtGJUAJO0lLTQOvzBgYUESFlpZGWSsfSQfNv2tl3zOKDvlbNeY10XK2wGryjPJM9lEsDvW1B3jfcdGtV21hXdWlFQG4sqWFRvFgN7sisdSofVB7nTFoDxFni2Na7_36R-Tq7eK-NtwgY7L_8SRfegGE95rubXUzUXf-74r78LNU1fAcm7i3Q</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>Logani, Mahendra K.</creator><creator>Anga, Altaf</creator><creator>Szabo, Imre</creator><creator>Agelan, Alexis</creator><creator>Irizarry, Armando R.</creator><creator>Ziskin, Marvin C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200212</creationdate><title>Effect of millimeter waves on cyclophosphamide induced suppression of the immune system</title><author>Logani, Mahendra K. ; Anga, Altaf ; Szabo, Imre ; Agelan, Alexis ; Irizarry, Armando R. ; Ziskin, Marvin C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3908-bf0d74ee0f8af4c8613104710258f3d6180691b91acc462706bf0099dce6b2463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Topical</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Body Weight - radiation effects</topic><topic>Bone Marrow Cells - drug effects</topic><topic>Bone Marrow Cells - radiation effects</topic><topic>Cyclophosphamide - administration & dosage</topic><topic>delayed type hypersensitivity</topic><topic>Dinitrochlorobenzene - administration & dosage</topic><topic>Dinitrochlorobenzene - pharmacology</topic><topic>Drug Hypersensitivity - immunology</topic><topic>Ear</topic><topic>Hypersensitivity, Delayed - chemically induced</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Immune Tolerance - drug effects</topic><topic>Immune Tolerance - immunology</topic><topic>Immune Tolerance - radiation effects</topic><topic>Immunity, Cellular - drug effects</topic><topic>Immunity, Cellular - radiation effects</topic><topic>Immunosuppression - methods</topic><topic>Injections, Intraperitoneal</topic><topic>Leukocyte Count</topic><topic>Leukocytes - drug effects</topic><topic>Leukocytes - radiation effects</topic><topic>leukopenia</topic><topic>Leukopenia - chemically induced</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microwaves</topic><topic>myelosuppression</topic><topic>Nose - immunology</topic><topic>Reference Values</topic><topic>Skin - drug effects</topic><topic>Skin - immunology</topic><topic>Skin - radiation effects</topic><topic>T-cell mediated immunity</topic><topic>T-Lymphocytes, Regulatory - drug effects</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - radiation effects</topic><topic>Whole-Body Irradiation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Logani, Mahendra K.</creatorcontrib><creatorcontrib>Anga, Altaf</creatorcontrib><creatorcontrib>Szabo, Imre</creatorcontrib><creatorcontrib>Agelan, Alexis</creatorcontrib><creatorcontrib>Irizarry, Armando R.</creatorcontrib><creatorcontrib>Ziskin, Marvin C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Bioelectromagnetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Logani, Mahendra K.</au><au>Anga, Altaf</au><au>Szabo, Imre</au><au>Agelan, Alexis</au><au>Irizarry, Armando R.</au><au>Ziskin, Marvin C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of millimeter waves on cyclophosphamide induced suppression of the immune system</atitle><jtitle>Bioelectromagnetics</jtitle><addtitle>Bioelectromagnetics</addtitle><date>2002-12</date><risdate>2002</risdate><volume>23</volume><issue>8</issue><spage>614</spage><epage>621</epage><pages>614-621</pages><issn>0197-8462</issn><eissn>1521-186X</eissn><abstract>The effect of millimeter electromagnetic waves (MWs) on cyclophosphamide (CPA) induced toxicity to leukocytes, bone marrow cells, and T‐cell‐mediated immunity was examined. For studying the effect of MWs on CPA induced leukopenia and myelosuppression, BALB/C mice were irradiated for 3 days, 30 min each day, prior to administration of CPA (200 mg/kg). MWs were produced with a Russian made YAV‐1 generator. The device produced 42.2 ± 0.2 GHz modulated wave radiation through a 10 mm × 20 mm rectangular output horn. The animals were irradiated on the nose area. Peak SAR and incident power density were measured as 622 ± 100 W/kg and 31 ± 5 mW/cm2, respectively. For studying the effect of MWs on CPA induced suppression of T‐cell mediated immunity, a delayed type hypersensitivity (DTH) assay in mouse skin was used. The DTH reaction in mouse skin was induced by topical application of dinitrochlorobenzene (DNCB) and quantified by measuring the increase in ear thickness and by histological examination. Treatment of animals with CPA significantly (P < 0.05) reduced leukocyte and bone marrow cell population, but MW irradiation did not show any significant protection from the immunosuppressive effects of CPA. Furthermore, MW irradiation did not protect the animals from CPA induced suppression of T‐cell mediated immunity. Bioelectromagnetics 23:614–621, 2002. © 2002 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12395417</pmid><doi>10.1002/bem.10058</doi><tpages>8</tpages></addata></record> |
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| ispartof | Bioelectromagnetics, 2002-12, Vol.23 (8), p.614-621 |
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| subjects | Administration, Topical Animals Body Weight - drug effects Body Weight - radiation effects Bone Marrow Cells - drug effects Bone Marrow Cells - radiation effects Cyclophosphamide - administration & dosage delayed type hypersensitivity Dinitrochlorobenzene - administration & dosage Dinitrochlorobenzene - pharmacology Drug Hypersensitivity - immunology Ear Hypersensitivity, Delayed - chemically induced Hypersensitivity, Delayed - immunology Immune Tolerance - drug effects Immune Tolerance - immunology Immune Tolerance - radiation effects Immunity, Cellular - drug effects Immunity, Cellular - radiation effects Immunosuppression - methods Injections, Intraperitoneal Leukocyte Count Leukocytes - drug effects Leukocytes - radiation effects leukopenia Leukopenia - chemically induced Male Mice Mice, Inbred BALB C Microwaves myelosuppression Nose - immunology Reference Values Skin - drug effects Skin - immunology Skin - radiation effects T-cell mediated immunity T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - radiation effects Whole-Body Irradiation |
| title | Effect of millimeter waves on cyclophosphamide induced suppression of the immune system |
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