Common variants in SLC1A2 and schizophrenia: Association and cognitive function in patients with schizophrenia and healthy individuals

AbstractSLC1A2 is reported to be responsible for the majority of glutamate uptake, which has a crucial role in neural development and synaptic plasticity, and a disturbance in glutamatergic transmission has been suggested to be involved in the pathophysiology of schizophrenia (SCZ) and cognition. To...

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Bibliographic Details
Published in:Schizophrenia research 2015-12, Vol.169 (1), p.128-134
Main Authors: Zhang, Bao, Guan, Fanglin, Chen, Gang, Lin, Huali, Zhang, Tianxiao, Feng, Jiali, Li, Lu, Fu, Dongke
Format: Article
Language:English
Subjects:
Adolescent
Adult
Asian Continental Ancestry Group - genetics
China
Cognition
Cognitive performance
Datasets as Topic
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genotyping Techniques
Glutamate Plasma Membrane Transport Proteins - genetics
Glutamate uptake
Haplotypes
Humans
Linkage Disequilibrium
Male
Middle Aged
Neuropsychological Tests
Perseverative errors
Polymorphism, Single Nucleotide
Psychiatric/Mental Health
Schizophrenia - genetics
Schizophrenia susceptibility
Schizophrenic Psychology
SLC1A2 gene
Young Adult
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Summary:AbstractSLC1A2 is reported to be responsible for the majority of glutamate uptake, which has a crucial role in neural development and synaptic plasticity, and a disturbance in glutamatergic transmission has been suggested to be involved in the pathophysiology of schizophrenia (SCZ) and cognition. To evaluate the relationship of common variants within SLC1A2 with SCZ and cognition in Han Chinese, 28 tag SNPs were genotyped in the discovery stage, which included 1117 cases and 2289 controls; significantly associated markers were genotyped in the replication stage with 2128 cases and 3865 controls. The rs4354668 SNP was identified to be significantly associated with SCZ in both datasets, and a similar pattern was also observed in the two-stage study on conducting imputation and haplotype association analyses. In addition, significant associations between the rs4354668 SNP and cognition were observed when processing the perseverative error of the Wisconsin Card Sorting Test in patients and controls. Our results provide supportive evidence for an effect of SLC1A2 on the etiology of SCZ, suggesting that genetic variation (rs4354668 and its haplotypes) in SLC1A2 may be involved in impaired executive function, which adds to the current body of knowledge regarding the risk of SCZ and the impairment of cognitive performance.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2015.10.012