Inhalation of Talc Induces Infiltration of Macrophages and Upregulation of Manganese Superoxide Dismutase in Rats

Talc is a mineral that is widely used in cosmetic products, antiseptics, paints, and rubber manufacturing. Although the toxicological effects of talc have been studied extensively, until now no detailed inhalation study of talc focusing on oxidative stress has been done. This repeated 4 weeks whole-...

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Bibliographic Details
Published in:International journal of toxicology 2015-11, Vol.34 (6), p.491-499
Main Authors: Shim, Ilseob, Kim, Hyun-mi, Yang, Sangyoung, Choi, Min, Seo, Gyun-baek, Lee, Byung-Woo, Yoon, Byung-Il, Kim, Pilje, Choi, Kyunghee
Format: Article
Language:English
Subjects:
Administration, Inhalation
Animals
Antioxidants - metabolism
Blood Glucose - metabolism
Bronchioles - pathology
Female
Glutathione Peroxidase - metabolism
Lung - pathology
Macrophages - drug effects
Male
Oxidative Stress - drug effects
Pulmonary Alveoli - pathology
Rats
Rats, Inbred F344
Rats, Sprague-Dawley
Superoxide Dismutase - biosynthesis
Superoxide Dismutase - genetics
Talc - administration & dosage
Talc - toxicity
Up-Regulation
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Summary:Talc is a mineral that is widely used in cosmetic products, antiseptics, paints, and rubber manufacturing. Although the toxicological effects of talc have been studied extensively, until now no detailed inhalation study of talc focusing on oxidative stress has been done. This repeated 4 weeks whole-body inhalation toxicity study of talc involved Sprague-Dawley rats. Male and female groups of rats were exposed to inhaled talc at 0, 5, 50, and 100 mg/m3 for 6 hours daily, 5 days/week for 4 weeks. The objective was to identify the 4-week inhalation toxicity of talc and investigate antioxidant activity after exposure to talc. There were no treatment-related symptoms or mortality in rats treated with talc. Glucose (GLU) was decreased significantly in male rats exposed to 50 and 100 mg/m3 of talc. Histopathological examination revealed infiltration of macrophages on the alveolar walls and spaces near the terminal and respiratory bronchioles. In male and female rats exposed to 100 mg/m3 talc, expression of superoxide dismutase 2, a typical biological indicator of oxidative damage, was significantly increased. Thus, inhalation of talc induces macrophage aggregations and oxidative damage in the lung.
ISSN:1091-5818
1092-874X
DOI:10.1177/1091581815607068