TMS to object cortex affects both object and scene remote networks while TMS to scene cortex only affects scene networks

• Published in: Neuropsychologia 2015-12, Vol.79 (Pt A), p.86-96
• Main Authors: Rafique, Sara A., Solomon-Harris, Lily M., Steeves, Jennifer K.E.
• Format: Article
• Language: English
• Subjects: Adult; Brain Mapping; Connectivity; Female; fMR-adaptation; Functional Laterality; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Neural Pathways - blood supply; Neural Pathways - physiology; Object processing; Occipital Lobe - blood supply; Occipital Lobe - physiology; Oxygen; Pattern Recognition, Visual - physiology; Photic Stimulation; Scene processing; Space Perception - physiology; Transcranial Magnetic Stimulation; Young Adult
• ISSN: 0028-3932; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2015.10.027

Viewing the world involves many computations across a great number of regions of the brain, all the while appearing seamless and effortless. We sought to determine the connectivity of object and scene processing regions of cortex through the influence of transient focal neural noise in discrete nodes within these networks. We consecutively paired repetitive transcranial magnetic stimulation (rTMS) with functional magnetic resonance-adaptation (fMR-A) to measure the effect of rTMS on functional response properties at the stimulation site and in remote regions. In separate sessions, rTMS was applied to the object preferential lateral occipital region (LO) and scene preferential transverse occipital sulcus (TOS). Pre- and post-stimulation responses were compared using fMR-A. In addition to modulating BOLD signal at the stimulation site, TMS affected remote regions revealing inter and intrahemispheric connections between LO, TOS, and the posterior parahippocampal place area (PPA). Moreover, we show remote effects from object preferential LO to outside the ventral perception network, in parietal and frontal areas, indicating an interaction of dorsal and ventral streams and possibly a shared common framework of perception and action. •Object and scene processing connectivity assessed with consecutive TMS and fMR-A.•TMS to TOS had effects in scene regions only.•However, TMS to LO had effects in both object and scene regions.•TMS to LO also affected frontal and parietal cortex.