Isolation of Phomopsolide A and 6(E)-Phomopsolide A as Antimycobacterial Natural Products from an Unidentified Endophyte of the Canadian Medicinal Plant Heracleum maximum

An extract of an unidentified endophyte from the Canadian medicinal plant Heracleum maximum exhibited a unique metabolomic profile and significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation of the extract led to the isolation of phomopsolide A...

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Bibliographic Details
Published in:Natural product communications 2015-10, Vol.10 (10), p.1647-1648
Main Authors: Clark, Trevor N, Ellsworth, Katelyn T, Jean, Stephanie, Webster, Duncan, Webste, Duncan, Robichaud, Gilles A, Johnson, John A, Gray, Christopher A
Format: Article
Language:English
Subjects:
Antitubercular Agents - chemistry
Antitubercular Agents - pharmacology
Biological Products
Canada
Endophytes - chemistry
Heracleum - chemistry
Molecular Structure
Plants, Medicinal - chemistry
Pyrones - chemistry
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Summary:An extract of an unidentified endophyte from the Canadian medicinal plant Heracleum maximum exhibited a unique metabolomic profile and significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation of the extract led to the isolation of phomopsolide A (1) and 6(E)-phomopsolide A (2). This is the first report of antimycobacterial activity for 1 and 2.
ISSN:1934-578X