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CD40 and B Chronic Lymphocytic Leukemia Cell Response To Fludarabine: The Influence of NF- Kappa B/Rel Transcription Factors On Chemotherapy-Induced Apoptosis

The levels of tumour necrosis factor receptor (TNF-R) superfamily members can be altered in lymphoid leukemias, indicating a possible role of such molecules in the biology of these neoplasias. In B chronic lymphocytic leukemia cells, the CD40/CD40L system has been shown to be effective in inhibiting...

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Bibliographic Details
Published in:Leukemia & lymphoma 2000-01, Vol.36 (3-4), p.255-262
Main Authors: Romano, M F, Lamberti, A, Turco, M C, Venuta, S
Format: Article
Language:English
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Summary:The levels of tumour necrosis factor receptor (TNF-R) superfamily members can be altered in lymphoid leukemias, indicating a possible role of such molecules in the biology of these neoplasias. In B chronic lymphocytic leukemia cells, the CD40/CD40L system has been shown to be effective in inhibiting the apoptotic response to fludarabine. The modulation of apoptosis relied on the CD40- induced activity of NF- Kappa B/Rel transcription factors. The anti- apoptotic effect of CD40 was abolished using a phosphorothioate Kappa B decoy oligodeoxynucleotide. These findings illustrate an example of the biological activity of TNF-R- like molecules in leukemias. They also show the influence of NF- Kappa B/Rel activity on leukemic cell response to apoptogenic agents.
ISSN:1042-8194
DOI:10.3109/10428190009148846