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CD40 and B Chronic Lymphocytic Leukemia Cell Response To Fludarabine: The Influence of NF- Kappa B/Rel Transcription Factors On Chemotherapy-Induced Apoptosis
The levels of tumour necrosis factor receptor (TNF-R) superfamily members can be altered in lymphoid leukemias, indicating a possible role of such molecules in the biology of these neoplasias. In B chronic lymphocytic leukemia cells, the CD40/CD40L system has been shown to be effective in inhibiting...
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Published in: | Leukemia & lymphoma 2000-01, Vol.36 (3-4), p.255-262 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | The levels of tumour necrosis factor receptor (TNF-R) superfamily members can be altered in lymphoid leukemias, indicating a possible role of such molecules in the biology of these neoplasias. In B chronic lymphocytic leukemia cells, the CD40/CD40L system has been shown to be effective in inhibiting the apoptotic response to fludarabine. The modulation of apoptosis relied on the CD40- induced activity of NF- Kappa B/Rel transcription factors. The anti- apoptotic effect of CD40 was abolished using a phosphorothioate Kappa B decoy oligodeoxynucleotide. These findings illustrate an example of the biological activity of TNF-R- like molecules in leukemias. They also show the influence of NF- Kappa B/Rel activity on leukemic cell response to apoptogenic agents. |
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ISSN: | 1042-8194 |
DOI: | 10.3109/10428190009148846 |