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Influence of the Structure of New Anthracycline Antibiotics on their Biological Properties
In the search for new derivatives of anthracycline antibiotics with advantageous biological properties, particularly with lower toxicity and/or higher activity, a series of new analogs of antibiotics applied in therapy such as daunorubicin, doxorubicin, as well as epidoxorubicin and, for comparison,...
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| Published in: | Anticancer research 2005-05, Vol.25 (3B), p.2043-2048 |
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| Language: | English |
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| container_end_page | 2048 |
| container_issue | 3B |
| container_start_page | 2043 |
| container_title | Anticancer research |
| container_volume | 25 |
| creator | WASOWSKA, Malgorzata OSZCZAPOWICZ, Irena WIETRZYK, Joanna OPOLSKI, Adam MADEJ, Janusz DZIMIRA, Stanislaw OSZCZAPOWICZ, Janusz |
| description | In the search for new derivatives of anthracycline antibiotics with advantageous biological properties, particularly with
lower toxicity and/or higher activity, a series of new analogs of antibiotics applied in therapy such as daunorubicin, doxorubicin,
as well as epidoxorubicin and, for comparison, analogs of epidaunorubicin, have been synthesized. Our results show that the
new derivatives have antiproliferative activities similar to or higher than the parent antibiotics. The toxicities of these
analogs were significantly lower, with LD 50 values from 1.8- to 18.4-fold higher than the referential drugs. Cardiotoxicity determinations, using male mice treated with
a single dose of 75% of the LD 50 values of all tested compounds, indicated that the cardiotoxicity of the new analogs is significantly lower than that of
the parent drugs. |
| format | article |
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lower toxicity and/or higher activity, a series of new analogs of antibiotics applied in therapy such as daunorubicin, doxorubicin,
as well as epidoxorubicin and, for comparison, analogs of epidaunorubicin, have been synthesized. Our results show that the
new derivatives have antiproliferative activities similar to or higher than the parent antibiotics. The toxicities of these
analogs were significantly lower, with LD 50 values from 1.8- to 18.4-fold higher than the referential drugs. Cardiotoxicity determinations, using male mice treated with
a single dose of 75% of the LD 50 values of all tested compounds, indicated that the cardiotoxicity of the new analogs is significantly lower than that of
the parent drugs.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 16158943</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Animals ; Anthracyclines - chemical synthesis ; Anthracyclines - chemistry ; Anthracyclines - pharmacology ; Anthracyclines - toxicity ; Antibiotics, Antineoplastic - chemical synthesis ; Antibiotics, Antineoplastic - chemistry ; Antibiotics, Antineoplastic - pharmacology ; Antibiotics, Antineoplastic - toxicity ; Biological and medical sciences ; Cell Line, Tumor ; Daunorubicin - analogs & derivatives ; Daunorubicin - chemical synthesis ; Daunorubicin - chemistry ; Daunorubicin - pharmacology ; Daunorubicin - toxicity ; Doxorubicin - analogs & derivatives ; Drug Screening Assays, Antitumor ; Epirubicin - analogs & derivatives ; Heart Diseases - chemically induced ; Humans ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred DBA ; Structure-Activity Relationship ; Tumors</subject><ispartof>Anticancer research, 2005-05, Vol.25 (3B), p.2043-2048</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16908602$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16158943$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WASOWSKA, Malgorzata</creatorcontrib><creatorcontrib>OSZCZAPOWICZ, Irena</creatorcontrib><creatorcontrib>WIETRZYK, Joanna</creatorcontrib><creatorcontrib>OPOLSKI, Adam</creatorcontrib><creatorcontrib>MADEJ, Janusz</creatorcontrib><creatorcontrib>DZIMIRA, Stanislaw</creatorcontrib><creatorcontrib>OSZCZAPOWICZ, Janusz</creatorcontrib><title>Influence of the Structure of New Anthracycline Antibiotics on their Biological Properties</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>In the search for new derivatives of anthracycline antibiotics with advantageous biological properties, particularly with
lower toxicity and/or higher activity, a series of new analogs of antibiotics applied in therapy such as daunorubicin, doxorubicin,
as well as epidoxorubicin and, for comparison, analogs of epidaunorubicin, have been synthesized. Our results show that the
new derivatives have antiproliferative activities similar to or higher than the parent antibiotics. The toxicities of these
analogs were significantly lower, with LD 50 values from 1.8- to 18.4-fold higher than the referential drugs. Cardiotoxicity determinations, using male mice treated with
a single dose of 75% of the LD 50 values of all tested compounds, indicated that the cardiotoxicity of the new analogs is significantly lower than that of
the parent drugs.</description><subject>Animals</subject><subject>Anthracyclines - chemical synthesis</subject><subject>Anthracyclines - chemistry</subject><subject>Anthracyclines - pharmacology</subject><subject>Anthracyclines - toxicity</subject><subject>Antibiotics, Antineoplastic - chemical synthesis</subject><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Antibiotics, Antineoplastic - toxicity</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Daunorubicin - analogs & derivatives</subject><subject>Daunorubicin - chemical synthesis</subject><subject>Daunorubicin - chemistry</subject><subject>Daunorubicin - pharmacology</subject><subject>Daunorubicin - toxicity</subject><subject>Doxorubicin - analogs & derivatives</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Epirubicin - analogs & derivatives</subject><subject>Heart Diseases - chemically induced</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred DBA</subject><subject>Structure-Activity Relationship</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpNkFFLwzAUhYMobk7_gvRF3wpJsyTN4zZ0DoYK6osvIU2TNZI2M0kZ-_d2OtGny71851zOOQFjxDjKGcHwFIxhQWDOICQjcBHjB4SU8hKfgxGiiJR8isfgfdUZ1-tO6cybLDU6e0mhV6kP34dHvctmXWqCVHvlbKcPm62sT1bFzHcHhQ3Z3HrnN1ZJlz0Hv9UhWR0vwZmRLuqr45yAt_u718VDvn5arhazdd5giFJeGEalQghxihlF01opRGkppakxYxzLimnCVV1iUhhVVxwPOUyly0rVnFYQT8Dtj-82-M9exyRaG5V2Tnba91EgRg5F4AG8PoJ91epabINtZdiL3zYG4OYIyDhkMUF2ysZ_HIclhcXfx8Zump0NWsRWOjfYYiFDQQSeiwIOhl_1q3cL</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>WASOWSKA, Malgorzata</creator><creator>OSZCZAPOWICZ, Irena</creator><creator>WIETRZYK, Joanna</creator><creator>OPOLSKI, Adam</creator><creator>MADEJ, Janusz</creator><creator>DZIMIRA, Stanislaw</creator><creator>OSZCZAPOWICZ, Janusz</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20050501</creationdate><title>Influence of the Structure of New Anthracycline Antibiotics on their Biological Properties</title><author>WASOWSKA, Malgorzata ; OSZCZAPOWICZ, Irena ; WIETRZYK, Joanna ; OPOLSKI, Adam ; MADEJ, Janusz ; DZIMIRA, Stanislaw ; OSZCZAPOWICZ, Janusz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h301t-2f76ac1119637614dcc1668aafd37793ab7e59cd8352fcdb93006fbe8bcd96b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Anthracyclines - chemical synthesis</topic><topic>Anthracyclines - chemistry</topic><topic>Anthracyclines - pharmacology</topic><topic>Anthracyclines - toxicity</topic><topic>Antibiotics, Antineoplastic - chemical synthesis</topic><topic>Antibiotics, Antineoplastic - chemistry</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Antibiotics, Antineoplastic - toxicity</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Daunorubicin - analogs & derivatives</topic><topic>Daunorubicin - chemical synthesis</topic><topic>Daunorubicin - chemistry</topic><topic>Daunorubicin - pharmacology</topic><topic>Daunorubicin - toxicity</topic><topic>Doxorubicin - analogs & derivatives</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Epirubicin - analogs & derivatives</topic><topic>Heart Diseases - chemically induced</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred DBA</topic><topic>Structure-Activity Relationship</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WASOWSKA, Malgorzata</creatorcontrib><creatorcontrib>OSZCZAPOWICZ, Irena</creatorcontrib><creatorcontrib>WIETRZYK, Joanna</creatorcontrib><creatorcontrib>OPOLSKI, Adam</creatorcontrib><creatorcontrib>MADEJ, Janusz</creatorcontrib><creatorcontrib>DZIMIRA, Stanislaw</creatorcontrib><creatorcontrib>OSZCZAPOWICZ, Janusz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WASOWSKA, Malgorzata</au><au>OSZCZAPOWICZ, Irena</au><au>WIETRZYK, Joanna</au><au>OPOLSKI, Adam</au><au>MADEJ, Janusz</au><au>DZIMIRA, Stanislaw</au><au>OSZCZAPOWICZ, Janusz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of the Structure of New Anthracycline Antibiotics on their Biological Properties</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>25</volume><issue>3B</issue><spage>2043</spage><epage>2048</epage><pages>2043-2048</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>In the search for new derivatives of anthracycline antibiotics with advantageous biological properties, particularly with
lower toxicity and/or higher activity, a series of new analogs of antibiotics applied in therapy such as daunorubicin, doxorubicin,
as well as epidoxorubicin and, for comparison, analogs of epidaunorubicin, have been synthesized. Our results show that the
new derivatives have antiproliferative activities similar to or higher than the parent antibiotics. The toxicities of these
analogs were significantly lower, with LD 50 values from 1.8- to 18.4-fold higher than the referential drugs. Cardiotoxicity determinations, using male mice treated with
a single dose of 75% of the LD 50 values of all tested compounds, indicated that the cardiotoxicity of the new analogs is significantly lower than that of
the parent drugs.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>16158943</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Anticancer research, 2005-05, Vol.25 (3B), p.2043-2048 |
| issn | 0250-7005 1791-7530 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | Animals Anthracyclines - chemical synthesis Anthracyclines - chemistry Anthracyclines - pharmacology Anthracyclines - toxicity Antibiotics, Antineoplastic - chemical synthesis Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology Antibiotics, Antineoplastic - toxicity Biological and medical sciences Cell Line, Tumor Daunorubicin - analogs & derivatives Daunorubicin - chemical synthesis Daunorubicin - chemistry Daunorubicin - pharmacology Daunorubicin - toxicity Doxorubicin - analogs & derivatives Drug Screening Assays, Antitumor Epirubicin - analogs & derivatives Heart Diseases - chemically induced Humans Male Medical sciences Mice Mice, Inbred BALB C Mice, Inbred DBA Structure-Activity Relationship Tumors |
| title | Influence of the Structure of New Anthracycline Antibiotics on their Biological Properties |
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