The Association between Severity of Atherosclerosis and Lower Urinary Tract Function in Male Patients with Lower Urinary Tract Symptoms

• Published in: Lower urinary tract symptoms 2012-01, Vol.4 (1), p.9-13
• Main Authors: TAKAHASHI, Norio, SHISHIDO, Keiichi, SATO, Yuichi, OGAWA, Soichiro, OGURO, Toshiki, KATAOKA, Masao, SHIOMI, Homare, UCHIDA, Hisashi, HAGA, Nobuhiro, HOSOI, Takayuki, NOMIYA, Masanori, AIKAWA, Ken, MURAKAMI, Husao, YAMAGUCHI, Osamu
• Format: Article
• Language: English
• Subjects: atherosclerosis; lower urinary tract dysfunction; male lower urinary tract symptoms
• ISSN: 1757-5664; 1757-5672
• DOI: 10.1111/j.1757-5672.2011.00098.x

Objectives: The present study was undertaken to investigate the association between the severity of atherosclerosis and lower urinary tract function in male patients with lower urinary tract symptoms. Methods: Male patients with lower urinary tract symptoms were examined with routine investigation. The severity of atherosclerosis was assessed by ultrasound examination of carotid artery. Patients were divided into two groups: control group and atherosclerosis group. The voiding function and storage function were compared between the two groups. Results: A total of 50 men (69.9 ± 9.1 years [mean ± standard deviation]) entered the study. There was no significant difference in age distribution (control group: 68.7 ± 7.6 years; atherosclerosis group: 72.5 ± 9.7 years) and prostate volume (control group: 26.5 ± 17.3 mL; atherosclerosis group: 22.2 ± 11.0 mL) between the two groups. In the voiding parameters, maximum flow rate in the atherosclerosis group (13.4 ± 5.5 mL/s, P < 0.05) was significantly lower than that in the control group (16.7 ± 7.7 mL/s). Postvoid residual urine volume showed no significant difference between the two groups. In the storage parameters, voided volume was significantly reduced in the atherosclerosis group (161.8 ± 46 mL, P < 0.05), as compared to control group (201.1 ± 78 mL). Moreover, daytime frequency was 7.13 ± 3.02 times in the control group, and significantly higher in the atherosclerosis group (8.75 ± 2.50 times, P < 0.05). Conclusion: Development of atherosclerosis impairs both voiding and storage function independently of age, suggesting atherosclerosis leads to lower urinary dysfunction.