Evaluation of Minichromosome Maintenance Protein 7 and c-KIT as Prognostic Markers in Feline Cutaneous Mast Cell Tumours

Mast cell tumours (MCTs) are a common skin tumour in cats, but there is currently no histological grading system or reliable prognostic marker for this species (unlike the situation for dogs). This study utilized a set of 71 feline cutaneous MCTs with known clinical outcomes to assess the potential...

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Bibliographic Details
Published in:Journal of comparative pathology 2015-11, Vol.153 (4), p.244-250
Main Authors: Dobromylskyj, M.J., Rasotto, R., Melville, K., Smith, K.C., Berlato, D.
Format: Article
Language:English
Subjects:
Animals
Biomarkers, Tumor - analysis
cat
Cat Diseases - metabolism
Cat Diseases - pathology
Cats
cutaneous mast cell tumour
Female
Immunohistochemistry
Kaplan-Meier Estimate
Male
Mastocytosis, Cutaneous - metabolism
Mastocytosis, Cutaneous - pathology
Mastocytosis, Cutaneous - veterinary
Minichromosome Maintenance Complex Component 7 - analysis
Minichromosome Maintenance Complex Component 7 - biosynthesis
Prognosis
prognostic markers
Proto-Oncogene Proteins c-kit - analysis
Proto-Oncogene Proteins c-kit - biosynthesis
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Summary:Mast cell tumours (MCTs) are a common skin tumour in cats, but there is currently no histological grading system or reliable prognostic marker for this species (unlike the situation for dogs). This study utilized a set of 71 feline cutaneous MCTs with known clinical outcomes to assess the potential of various prognostic markers, including the cellular proliferation marker minichromosome maintenance protein (MCM)-7, mitotic index and various KIT labelling characteristics, including KIT positivity, KIT labelling pattern and KIT immunoreactivity score (IS). Of the factors studied, the mitotic index and the KIT labelling pattern were the only features associated significantly with survival times, while the proliferation marker MCM7 and the KIT IS were not. The study also highlights the variability of KIT labelling characteristics between tumours, which may prevent use of this marker as a diagnostic and prognostic tool.
ISSN:0021-9975
1532-3129
DOI:10.1016/j.jcpa.2015.08.005