Biotransformation effects on anti lipogenic activity of citrus extracts

•Biotransformation modified flavonoids profile of a citrus peel extract.•Biotransformed peel extract was a good source of flavonoids found in low amounts.•Citrus flavonoid extract from industrial residue had anti-lipogenic activity.•Biotransformed citrus peel extract caused lipolysis in mouse adipoc...

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Bibliographic Details
Published in:Food chemistry 2016-04, Vol.197, p.1046-1053
Main Authors: Nakajima, Vânia Mayumi, Madeira, José Valdo, Macedo, Gabriela Alves, Macedo, Juliana Alves
Format: Article
Language:English
Subjects:
Adipocytes
Adipocytes - drug effects
Animals
Biotransformation
Citrus
Citrus peel extract
Flavanones - pharmacology
Hesperidin
Hesperidin - pharmacology
Hesperitin
Lipolysis
Lipolysis - drug effects
Mice
Naringenin
Naringin
Plant Extracts - chemistry
Plant Extracts - pharmacology
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Summary:•Biotransformation modified flavonoids profile of a citrus peel extract.•Biotransformed peel extract was a good source of flavonoids found in low amounts.•Citrus flavonoid extract from industrial residue had anti-lipogenic activity.•Biotransformed citrus peel extract caused lipolysis in mouse adipocyte cell line. Citrus peel is a good source of flavonoids, with higher content in relation to pulp. This study proposed to investigate the anti-lipogenic potential of a newly developed citrus flavonoids extract, obtained from citrus industrial residue, bioprocessed in order to generate a commercial source of some flavonoids naturally found in low quantity. The results showed that the citrus peel extract obtained after biotransformation was a good source of hesperitin and naringenin, flavonoids that has no source for production on a large scale, as in supplements or medicines. Still, the results showed that all extracts could be used in obesity treatment. The original extract, “In Natura”, would be useful to reduce new adipocytes synthesis and lipid accumulation, and the extract bioprocessed, “Biotransformed” extract could be used to induce lipolysis on fat tissue.
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2015.11.109