Synthetic ligands of the elastin receptor induce elastogenesis in human dermal fibroblasts via activation of their IGF-1 receptors

• Published in: Journal of dermatological science 2015-12, Vol.80 (3), p.175-185
• Main Authors: Qa’aty, Nour, Vincent, Matthew, Wang, Yanting, Wang, Andrew, Mitts, Thomas F, Hinek, Aleksander
• Format: Article
• Language: English
• Subjects: Adult; Cells, Cultured; Dermatology; Elastin - biosynthesis; Elastin - drug effects; Elastin - genetics; Elastin receptor; Elastin-like peptides; Elastogenesis; Female; Fibroblasts - drug effects; Fibroblasts - metabolism; Gene Expression Regulation - drug effects; Human skin regeneration; Humans; IGF-1 receptor; Insulin-Like Growth Factor Binding Protein 1 - metabolism; Ligands; Middle Aged; Molecular Chaperones - metabolism; Oligopeptides - chemical synthesis; Oligopeptides - pharmacology; Phosphorylation - drug effects; Receptor, IGF Type 1 - metabolism; Receptors, Cell Surface - metabolism; Regeneration; RNA, Messenger - metabolism; Signal Transduction - drug effects; Skin - cytology; Skin - metabolism; Skin Physiological Phenomena; src-Family Kinases - metabolism; Tissue Culture Techniques; Tropoelastin - genetics; Tropoelastin - metabolism; Up-Regulation - drug effects
• ISSN: 0923-1811; 1873-569X
• DOI: 10.1016/j.jdermsci.2015.10.001

Highlights • Synthetic peptides with xGxxPG sequence induce elastogenesis in dermal fibroblasts. • Similar sequence is also present in the IGF-1-binding protein-1. • All these peptides interact with the elastin receptor, then cross-activate IGF-1R. • Interaction between xGxxPG peptides and IGFBP-1 also releases free IGF-1. • Free IGF-1 binds to its receptor, thereby activating elastogenic pathway.