Predictive value of pAKT/PTEN expression in oral squamous cell carcinoma treated with cetuximab-based chemotherapy

Objective Molecular alterations in downstream effectors of epidermal growth factor receptor may confer resistance to epidermal growth factor receptor inhibitors. Our aim is to investigate whether PTEN/pAKT expression predicts response to cetuximab-based chemotherapy in oral squamous cell carcinoma....

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2016, Vol.121 (1), p.67-72
Main Authors: Lyu, Jiong, MS, Song, Hao, MS, Tian, Zhen, PhD, Miao, Yuwen, MS, Ren, Guoxin, PhD, Guo, Wei, PhD
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - metabolism
Biopsy
Carcinoma, Squamous Cell - drug therapy
Carcinoma, Squamous Cell - metabolism
Cetuximab - therapeutic use
Dentistry
Female
Humans
Immunohistochemistry
Male
Middle Aged
Mouth Neoplasms - drug therapy
Mouth Neoplasms - metabolism
Predictive Value of Tests
Proto-Oncogene Proteins c-akt - metabolism
PTEN Phosphohydrolase - metabolism
Surgery
Treatment Outcome
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Summary:Objective Molecular alterations in downstream effectors of epidermal growth factor receptor may confer resistance to epidermal growth factor receptor inhibitors. Our aim is to investigate whether PTEN/pAKT expression predicts response to cetuximab-based chemotherapy in oral squamous cell carcinoma. Study Design We analyzed a cohort of 50 patients with oral squamous cell carcinoma treated with cetuximab-based induction chemotherapy. PTEN expression and pAKT expression were assessed by immunohistochemistry and their correlation with treatment outcome was analyzed. Results Of the study patients, 18.4% had low PTEN expression, and 38.8% had high pAKT expression. Lower pAKT expression were associated with pathologic remission ( P  = .034) and better disease-free survival ( P  = .031). Conclusion Our study demonstrates that pAKT expression is a predictive biomarker of cetuximab-based induction chemotherapy in OSCC.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2015.09.002