Copper(I)-Catalyzed Intramolecular Trifluoromethylation of Methylenecyclopropanes

Copper­(I)-catalyzed intramolecular trifluoromethylation of methylene­cyclopropanes has been developed to produce a variety of CF3-substituted dihydro­naphthalenes in moderate to good yields, relying on the construction of C­(sp2)–CF3 bonds under mild conditions. The reactions proceed through a radi...

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Bibliographic Details
Published in:Organic letters 2015-12, Vol.17 (24), p.5994-5997
Main Authors: Zhu, Zi-Zhong, Chen, Kai, Yu, Liu-Zhu, Tang, Xiang-Ying, Shi, Min
Format: Article
Language:English
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Summary:Copper­(I)-catalyzed intramolecular trifluoromethylation of methylene­cyclopropanes has been developed to produce a variety of CF3-substituted dihydro­naphthalenes in moderate to good yields, relying on the construction of C­(sp2)–CF3 bonds under mild conditions. The reactions proceed through a radical process under copper­(I) catalysis with a good compatibility for the functional group.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b02940