Pulmonary manifestations of renal cell carcinoma

Abstract Renal cell carcinoma (RCC) accounts for majority of all primary renal neoplasms. Classic manifestations of RCC include the triad of flank pain, hematuria and a palpable renal mass. Patients with RCC can develop various extra renal manifestations including involvements of the lungs, inferior...

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Bibliographic Details
Published in:Respiratory medicine 2015-12, Vol.109 (12), p.1505-1508
Main Authors: Agrawal, Abhinav, Sahni, Sonu, Iftikhar, Asma, Talwar, Arunabh
Format: Article
Language:English
Subjects:
Antineoplastic Agents - adverse effects
Breast cancer
Carcinoma, Renal Cell - secondary
Cellular biology
Drugs
Embolisms
Gangrene
Humans
Hypotheses
Kidney Neoplasms
Lung metastasis
Lung Neoplasms - secondary
Lymphatic system
Medical prognosis
Metastasis
Molecular weight
Neoplastic Cells, Circulating
Patients
Pleural effusion
Pleural Effusion - etiology
Pneumonia - chemically induced
Pulmonary Embolism - etiology
Pulmonary manifestations
Pulmonary/Respiratory
Renal cell carcinoma
Respiratory Tract Fistula - etiology
Sarcoid like reaction
Sarcoidosis
Sarcoidosis, Pulmonary - etiology
Tumor thromboembolism
Tumors
Vascular endothelial growth factor
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Summary:Abstract Renal cell carcinoma (RCC) accounts for majority of all primary renal neoplasms. Classic manifestations of RCC include the triad of flank pain, hematuria and a palpable renal mass. Patients with RCC can develop various extra renal manifestations including involvements of the lungs, inferior vena cava, liver and the bones. The pulmonary manifestations of renal cell carcinoma include metastatic disease including endobronchial, pleural, parenchymal or lymph node metastasis, pleural effusion or hemothorax. Pulmonary embolism and tumor embolism is another common manifestation of renal cell carcinoma. RCC is a highly vascular tumor and can cause pulmonary arterio-venous fistulas leading to high output failure. Rarely, RCC can also present with paraneoplastic presentations including cough or bilateral diaphragm paralysis. Drugs used to treat RCC have been associated with drug related pneumonitis and form an important differential diagnosis in patients with RCC on therapy presenting with shortness of breath. In this review we discuss the various pulmonary manifestations of RCC. A high index of suspicion with these presentations can lead to an early diagnosis and assist in instituting an appropriate intervention.
ISSN:0954-6111
1532-3064
DOI:10.1016/j.rmed.2015.10.002