Likely Recurrence of C3 Glomerulonephritis in Kidney Transplantation: An Entity to Bear in Mind: Case Report

Abstract Background C3 glomerulonephritis (C3GN) is an unusual entity that is caused by dysregulation and hyperactivity of the alternative complement pathway. Renal biopsy immunofluorescence study shows C3 deposits with absence of immunoglobulins and markers of the classical complement pathway. More...

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Bibliographic Details
Published in:Transplantation proceedings 2015-11, Vol.47 (9), p.2669-2671
Main Authors: Perea-Ortega, L, León-Fradejas, M, Alonso-Titos, J, Cabello-Díaz, M, Toledo-Rojas, R, Sola-Moyano, E, Martín-Reyes, G, López-Jiménez, V, Burgos-Rodríguez, D, Hernández-Marrero, D
Format: Article
Language:English
Subjects:
Biopsy
Complement C3 - immunology
Female
Glomerulonephritis - complications
Glomerulonephritis - diagnosis
Glomerulonephritis - immunology
Humans
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - surgery
Kidney Transplantation - adverse effects
Middle Aged
Recurrence
Risk Factors
Surgery
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Summary:Abstract Background C3 glomerulonephritis (C3GN) is an unusual entity that is caused by dysregulation and hyperactivity of the alternative complement pathway. Renal biopsy immunofluorescence study shows C3 deposits with absence of immunoglobulins and markers of the classical complement pathway. More than 50% of cases develop end-stage renal disease. Less well-known is the course of C3GN after kidney transplantation. Case Report We present the case of a 60-year-old woman with chronic kidney disease secondary to chronic glomerulonephritis of unknown origin who received a kidney transplant. Two years later, she presented worsening renal function with non-nephrotic proteinuria and microhematuria. Complement testing revealed low serum levels of C3. Kidney biopsy showed alterations compatible with C3GN that we interpreted as a relapse of the underlying disease.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2015.09.053