Effects of ochratoxin a on oxidative damage in rat kidney: protective role of melatonin

Epidemiological studies indicate that ochratoxin A (OTA) may be involved in the pathogenesis of different forms of human nephropathies. Melatonin (MEL) displays antioxidant and free radical scavenger properties. In the present study, the effect of MEL on the oxidative stress induced by OTA administr...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied toxicology 2004-05, Vol.24 (3), p.211-215
Main Authors: ÖZCELIK, Nurten, SOYÖZ, Mustafa, KILMC, Ibrahim
Format: Article
Language:English
Subjects:
Animals
Antioxidants - therapeutic use
Biological and medical sciences
Carcinogens - antagonists & inhibitors
Carcinogens - toxicity
catalase
Catalase - metabolism
Free Radical Scavengers - metabolism
Fundamental and applied biological sciences. Psychology
glutathione peroxidase
Glutathione Peroxidase - metabolism
kidney
Kidney Diseases - chemically induced
Kidney Diseases - enzymology
Kidney Diseases - prevention & control
lipid peroxidation
Lipid Peroxidation - drug effects
Male
melatonin
Melatonin - therapeutic use
Microbiology
Mycology
ochratoxin A
Ochratoxins - antagonists & inhibitors
Ochratoxins - toxicity
Pathogenicity, host-agent relations, miscellaneous strains, epidemiology
Rats
Rats, Wistar
superoxide dismutase
Superoxide Dismutase - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epidemiological studies indicate that ochratoxin A (OTA) may be involved in the pathogenesis of different forms of human nephropathies. Melatonin (MEL) displays antioxidant and free radical scavenger properties. In the present study, the effect of MEL on the oxidative stress induced by OTA administration in rats was investigated. Three groups of eight rats each were used: control, OTA (289 µg kg−1 day−1) and OTA + MEL (OTA, 289 µg kg−1 day−1; MEL, 10 mg kg−1 day−1), with treatment at two different time periods during the same day. After 4 weeks of treatment, the levels of lipid peroxidation (LPO) and the activities of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) were measured in homogenates of kidney. In OTA‐treated rats, the levels of LPO and the activities of GSHPx and SOD were significantly decreased compared with controls. In OTA + MEL‐treated rats, SOD, GSHPx and catalase activities and LPO levels were not changed significantly in comparison with controls. Copyright © 2004 John Wiley & Sons, Ltd.
ISSN:0260-437X
1099-1263
DOI:10.1002/jat.974