Inhibition of the hyperalgesic activity of Bothrops jararaca venom by an antibothropic fraction isolated from opossum ( Didelphis marsupialis) serum

The antibothropic fraction (ABF) already isolated from Didelphis marsupialis serum, inhibits the haemorrhagic, oedematogenic, myonecrotic and lethal activities of Bothrops jararaca venom (Bjv). The aim of this work was to verify the capability of ABF to inhibit the hyperalgesic activity of Bjv. Intr...

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Bibliographic Details
Published in:Toxicon (Oxford) 2000-06, Vol.38 (6), p.875-880
Main Authors: Rocha, Surza L.G, Frutuoso, Valber S, Domont, Gilberto B, Martins, Marco A, Moussatché, Haity, Perales, Jonas
Format: Article
Language:English
Subjects:
Animal poisons toxicology. Antivenoms
Animals
Anti-Inflammatory Agents - therapeutic use
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Antivenins - blood
Antivenins - therapeutic use
Azepines - therapeutic use
Biological and medical sciences
Bothrops
Bothrops jararaca
Bothrops jararaca venom
Crotalid Venoms - antagonists & inhibitors
Crotalid Venoms - toxicity
Dexamethasone - therapeutic use
Didelphis marsupialis
Didelphis marsupialis resistance
hyperalgesia
Hyperalgesia - chemically induced
Hyperalgesia - prevention & control
Hyperalgesic activity
Indomethacin - therapeutic use
Medical sciences
Natural immunity
Opossums - blood
Platelet Aggregation Inhibitors - therapeutic use
Toxicology
Triazoles - therapeutic use
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Summary:The antibothropic fraction (ABF) already isolated from Didelphis marsupialis serum, inhibits the haemorrhagic, oedematogenic, myonecrotic and lethal activities of Bothrops jararaca venom (Bjv). The aim of this work was to verify the capability of ABF to inhibit the hyperalgesic activity of Bjv. Intraplantar injection of Bjv induced hyperalgesia in a time- and dose-dependent manner and ABF administered in situ concomitantly with Bjv or i.v. 30 min before venom injection reduced the induced hyperalgesia. This same effect was observed when ABF was intravenously injected at 5 and 15 min after Bjv. Our results show that ABF inhibits also the hyperalgesia induced by Bjv.
ISSN:0041-0101
1879-3150
DOI:10.1016/S0041-0101(99)00190-7